Schönenberger Katja A, Ranzini Cristina, Laval Julie, Bellenger Pascale, Tenon Mathieu, Fança-Berthon Pascale
Givaudan International SA, Kemptthal, Switzerland.
Givaudan France Naturals, Avignon, France.
Food Funct. 2025 Jan 20;16(2):774-784. doi: 10.1039/d4fo03414g.
Curcuminoid absorption can be influenced by the presence of additional compounds, but there has been no study investigating this in a robust manner. The aim of this clinical trial was to assess the effect of the type of food matrix on the absorption of curcuminoids from a highly bioavailable turmeric formulation. Participants consumed the turmeric formulation in the form of capsules, a ready-to-drink fruit nectar, a sports nutrition bar, a dairy analogue (oat milk), pectin gummies, and a probiotic drink in a randomized, crossover study. Plasma samples were collected over a 24-hour period to assess the pharmacokinetics of curcuminoids. The relative bioavailability of total curcuminoids was increased in all the food matrices compared to that in the capsule formulation. The dairy analogue showed the highest increase in dose-normalized AUC (+76%, < 0.0001) and (+105%, < 0.0001). The sports nutrition bar resulted in increased dose-normalized AUC (+40%, = 0.0112) and (+74%, < 0.0001). The probiotic drink showed increased dose-normalized AUC (+35%, = 0.0318) and (+52%, < 0.0001). The ready-to-drink and gummy formulations were bioequivalent to the capsules. The distribution of curcuminoid metabolites was similar in all the matrices. In conclusion, there was no negative food matrix effect; on the contrary, the bioavailability of curcuminoids can be improved when administered food matrices, particularly those containing lipids in a suspended form or polar lipids.
姜黄素类化合物的吸收会受到其他化合物的影响，但尚未有研究以严谨的方式对此进行调查。这项临床试验的目的是评估食物基质类型对一种高生物利用度姜黄制剂中姜黄素类化合物吸收的影响。在一项随机交叉研究中，参与者以胶囊、即饮果汁、运动营养棒、乳类替代品（燕麦奶）、果胶软糖和益生菌饮料的形式服用姜黄制剂。在24小时内采集血浆样本以评估姜黄素类化合物的药代动力学。与胶囊制剂相比，所有食物基质中总姜黄素类化合物的相对生物利用度均有所提高。乳类替代品的剂量标准化AUC增加最多（+76%，<0.0001），Cmax增加最多（+105%，<0.0001）。运动营养棒使剂量标准化AUC增加（+40%，P = 0.0112），Cmax增加（+74%，<0.0001）。益生菌饮料的剂量标准化AUC增加（+35%，P = 0.0318），Cmax增加（+52%，<0.0001）。即饮型和软糖型制剂与胶囊具有生物等效性。所有基质中姜黄素类代谢物的分布相似。总之，不存在负面的食物基质效应；相反，当与食物基质一起给药时，姜黄素类化合物的生物利用度可以提高，特别是那些含有悬浮形式脂质或极性脂质的食物基质。
