Li Lifeng, Xu Xinxiu, Cheng Ping, Yu Zengyuan, Li Mingchao, Yu Zhidan, Cheng Weyland, Zhang Wancun, Sun Huiqing, Song Xiaorui
Henan International Joint Laboratory of Children's Infectious Diseases, Department of Neonatology, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.
Department of Neurology, Qingdao Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Virulence. 2025 Dec;16(1):2449722. doi: 10.1080/21505594.2025.2449722. Epub 2025 Jan 10.
is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. The escalating detections of hypervirulent and antibiotic-resistant isolates are giving rise to growing public concerns. Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids. Emerging studies have reported various roles of OMVs in bacterial virulence, antibiotic resistance, stress adaptation, and host interactions, whereas knowledge on their roles in is currently unclear. In this review, we summarized recent progress on the biogenesis, components, and biological function of OMVs, the impact and action mechanism in virulence, antibiotic resistance, and host immune response. We also deliberated on the potential of OMVs in vaccine development, as diagnostic biomarkers, and as drug nanocarriers. In conclusion, OMVs hold great promise in the prevention and control of infectious diseases, which merits further investigation.
是一种革兰氏阴性病原体，可引起多种疾病，包括败血症、尿路感染和肺炎。高毒力和抗生素耐药菌株的检出率不断上升，引起了公众越来越多的关注。外膜囊泡（OMV）是含有生物活性物质的球形囊泡，这些生物活性物质包括脂多糖、肽聚糖、周质和细胞质蛋白以及核酸。新兴研究报道了OMV在细菌毒力、抗生素耐药性、应激适应和宿主相互作用中的各种作用，而关于它们在……中的作用的知识目前尚不清楚。在这篇综述中，我们总结了……OMV的生物发生、成分和生物学功能的最新进展，以及在毒力、抗生素耐药性和宿主免疫反应中的影响和作用机制。我们还探讨了……OMV在疫苗开发、作为诊断生物标志物以及作为药物纳米载体方面的潜力。总之，……OMV在传染病的预防和控制方面具有巨大潜力，值得进一步研究。 （原文中部分内容缺失具体指代，翻译可能不太完整准确，你可补充完整原文信息以便更准确翻译 ）
