路易斯酸催化的二氢吡啶与双环丁烷的[2π + 2σ]环加成反应。
Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes.
作者信息
Liang Yujie, Nematswerani Ronewa, Daniliuc Constantin G, Glorius Frank
机构信息
Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, 48149 Münster, Germany.
出版信息
Chem Commun (Camb). 2025 Jan 28;61(10):2091-2094. doi: 10.1039/d4cc06133k.
PMID:39792130
Abstract
Herein we report a simple BF-catalyzed cycloaddition of dihydropyridines with bicyclobutanes for the expedient synthesis of novel three-dimensional azacycle-fused bicyclo[2.1.1]hexane scaffolds. The reaction utilizes easily accessible starting materials and proceeds under mild, metal-free conditions with high atom efficiency.
摘要
在此，我们报道了一种简单的由硼氟酸催化的二氢吡啶与双环丁烷的环加成反应，用于便捷地合成新型三维氮杂环稠合双环[2.1.1]己烷骨架。该反应使用易于获得的起始原料，在温和、无金属的条件下进行，具有高原子经济性。
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