Department of Obstetrics and Gynecology Izmir, Izmir Katip Celebi University Faculty of Medicine, Turkey.
Department of Pharmacology Izmir, Izmir Katip Celebi University Faculty of Medicine, Turkey.
Fetal Pediatr Pathol. 2023 Dec;42(6):845-859. doi: 10.1080/15513815.2023.2245892. Epub 2023 Aug 14.
To investigate the relaxation responses mediated by L-type Ca2+ channels and big-conductance Ca-activated K (BKCa) channels and histological changes in the human umbilical artery (HUA) and myometrium smooth muscle isolated from pregnancies complicated with intrauterine growth restriction (IUGR). The muscle reactivity and the histology of the smooth muscle of the HUA and myometrium retrieved from 14 women with IUGR and 14 controls were investigated by the isolated tissue bath and immunohistochemical method. In HUA, the maximum relaxation responses and pD2 values of nifedipine and NS11021 (BKCa channel opener) were significantly increased and significant histopathological changes are observed in the IUGR group.: The pathogenesis of IUGR might be associated with the impairment in the functional responses of L-type Ca2+ channels and BKCa channels in HUA smooth muscle. The increased staining of myometrium and UC with HIF-1α in IUGR may indicate apoptosis, histological damage, and impaired fetal growth.
探讨与 L 型钙通道和大电导钙激活钾（BKCa）通道介导的松弛反应以及与宫内生长受限（IUGR）相关的人脐动脉（HUA）和子宫平滑肌组织学变化。
通过离体组织浴槽和免疫组织化学方法，研究了来自 14 例 IUGR 妇女和 14 例对照妇女的 HUA 和子宫平滑肌的肌肉反应性和平滑肌组织学。在 HUA 中，硝苯地平和 NS11021（BKCa 通道开放剂）的最大松弛反应和 pD2 值显著增加，在 IUGR 组中观察到明显的组织病理学变化。
IUGR 的发病机制可能与 HUA 平滑肌中 L 型钙通道和 BKCa 通道功能反应的损害有关。IUGR 中子宫和 UC 与 HIF-1α 的染色增加可能表明细胞凋亡、组织学损伤和胎儿生长受损。
