Preston D M, Lennard-Jones J E
Dig Dis Sci. 1985 Apr;30(4):289-94. doi: 10.1007/BF01403835.
The resting motility of the pelvic colon was studied in 28 patients with constipation and compared with control subjects and patients with diarrhea. Colonic activity in patients who had been shown to have slow colonic transit was not significantly different from controls. In contrast, activity in patients who complained of constipation but who were found to have normal colonic transit time was increased (P less than 0.02). The response of the pelvic colon to the introduction of a surface-acting laxative was studied in 18 patients with slow-transit constipation. Eleven patients developed progressive peristaltic waves, while in 7 there was no response. It is possible that the relative inactivity of the colon in the latter group is due to a disorder of the myenteric plexus. If so, the bisacodyl stimulation test may distinguish patients with an abnormal myenteric plexus from those in whom it is normal.
对28例便秘患者的盆腔结肠静息运动进行了研究，并与对照组及腹泻患者进行比较。经证实结肠传输缓慢的患者的结肠活动与对照组无显著差异。相比之下，主诉便秘但结肠传输时间正常的患者的结肠活动增强（P<0.02）。对18例传输缓慢型便秘患者的盆腔结肠对表面活性剂泻药引入的反应进行了研究。11例患者出现进行性蠕动波，而7例无反应。后一组结肠相对不活动可能是由于肌间神经丛紊乱所致。如果是这样，比沙可啶刺激试验可能会区分肌间神经丛异常的患者和正常的患者。
