World J Gastroenterol. 2010 Nov 7;16(41):5162-72. doi: 10.3748/wjg.v16.i41.5162.
Colonic motility subserves large bowel functions, including absorption, storage, propulsion and defaecation. Colonic motor dysfunction remains the leading hypothesis to explain symptom generation in chronic constipation, a heterogeneous condition which is extremely prevalent in the general population, and has huge socioeconomic impact and individual suffering. Physiological testing plays a crucial role in patient management, as it is now accepted that symptom-based assessment, although important, is unsatisfactory as the sole means of directing therapy. Colonic manometry provides a direct method for studying motor activities of the large bowel, and this review provides a contemporary understanding of how this technique has enhanced our knowledge of normal colonic motor physiology, as well as helping to elucidate pathophysiological mechanisms underlying constipation. Methodological approaches, including available catheter types, placement technique and recording protocols, are covered, along with a detailed description of recorded colonic motor activities. This review also critically examines the role of colonic manometry in current clinical practice, and how manometric assessment may aid diagnosis, classification and guide therapeutic intervention in the constipated individual. Most importantly, this review considers both adult and paediatric patients. Limitations of the procedure and a look to the future are also addressed.
结肠动力有助于大肠的多种功能，包括吸收、储存、推进和排便。结肠运动功能障碍仍然是解释慢性便秘症状发生的主要假说，慢性便秘是一种在普通人群中极其普遍的异质性疾病，具有巨大的社会经济影响和个体痛苦。生理测试在患者管理中起着至关重要的作用，因为现在人们已经接受了基于症状的评估虽然很重要，但作为指导治疗的唯一手段并不令人满意。结肠测压法为研究大肠的运动活动提供了一种直接的方法，本综述提供了对该技术如何增强我们对正常结肠运动生理学的认识的当代理解，同时有助于阐明便秘背后的病理生理机制。涵盖了方法学方法，包括可用的导管类型、放置技术和记录方案，以及对记录的结肠运动活动的详细描述。本综述还批判性地审查了结肠测压术在当前临床实践中的作用，以及测压评估如何有助于诊断、分类和指导便秘患者的治疗干预。最重要的是，本综述同时考虑了成人和儿科患者。该程序的局限性和对未来的展望也得到了探讨。
