戊糖途径形成所有必需代谢物的能力为新陈代谢的起源提供了线索。
The ability of pentose pathways to form all essential metabolites provides clues to the origins of metabolism.
作者信息
Lindner Steffen N, Ralser Markus
机构信息
Department of Biochemistry, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.
Max Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany.
出版信息
PLoS Biol. 2025 Jan 10;23(1):e3002996. doi: 10.1371/journal.pbio.3002996. eCollection 2025 Jan.
Abstract
The structure of the early metabolic network is unknown. Here, we report that when considered together, pentose utilization pathways form all life-essential precursors. We speculate that the chemistry preserved in pentose metabolism could therefore have been a central structural element in early metabolism.
摘要
早期代谢网络的结构尚不清楚。在此，我们报告称，若综合考虑，戊糖利用途径构成了所有生命必需的前体物质。我们推测，戊糖代谢中保留的化学过程因此可能是早期代谢的核心结构要素。
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