White H J, Rank R G, Soloff B L, Barron A L
Infect Immun. 1979 Nov;26(2):728-35. doi: 10.1128/iai.26.2.728-735.1979.
At necropsy indication of spread of infection to fallopian tubes was found in 25 of 41 (60%) female guinea pigs infected in the genital tract with the chlamydial agent of guinea pig inclusion conjunctivitis and immunosuppressed with cyclophosphamide. Eighteen were examined histologically, and the diagnosis of acute salpingitis was confirmed in 10, based on inflammatory reaction, detection of guinea pig inclusion conjunctivitis in tissue, and formation of cysts (pyosalpinx and hydrosalpinx). Infection of fallopian tube tissue was confirmed by indirect immunofluorescence and electron microscopy. Infection of endometrial tissue and peritoneum was also recognized. Data suggested that the immunosuppression mediated by cyclophosphamide resulted in a prolonged genital tract infection and concomitant ascending infection leading to salpingitis.
在尸检时，41只经阴道感染豚鼠包涵体结膜炎衣原体并经环磷酰胺免疫抑制的雌性豚鼠中，有25只（60%）发现感染扩散至输卵管。对18只进行了组织学检查，基于炎症反应、组织中豚鼠包涵体结膜炎的检测以及囊肿（脓性输卵管炎和输卵管积水）的形成，10只被确诊为急性输卵管炎。通过间接免疫荧光和电子显微镜证实了输卵管组织感染。还发现了子宫内膜组织和腹膜感染。数据表明，环磷酰胺介导的免疫抑制导致生殖道感染延长并伴有上行感染，进而引发输卵管炎。
