Han Shuang Yu, Treves Brown Bernard J, Higginson Matthew Alan, Kaye Philip, Sharrad Clint A, Heath Scott L
Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
J Chromatogr A. 2025 Feb 8;1742:465646. doi: 10.1016/j.chroma.2024.465646. Epub 2024 Dec 31.
Mass spectroscopy and microfluidic technology, when combined, offer significant advantages in radiochemical analysis sample volume and cost reduction. A microfluidic device designed for efficiency has been developed. This device separates uranium from key trace elements by utilising UTEVA® chromatographic resins and nitric acid solutions of different concentrations for adsorption and recovery. The eluates from this microdevice are then diluted and directed to an inductively coupled plasma mass spectrometry system, enabling direct analysis of trace elements and uranium with minimal operator-sample interaction. This efficient approach greatly reduces the volume of sample required for trace elemental analysis in actinide materials, thereby reducing costs and satisfying the As Low As Reasonably Achievable (ALARA) principle.
质谱分析和微流控技术相结合，在放射化学分析中，能显著减少样品体积并降低成本。现已开发出一种旨在提高效率的微流控装置。该装置利用UTEVA® 色谱树脂和不同浓度的硝酸溶液进行吸附和回收，从而将铀与关键微量元素分离。然后，将该微型装置的洗脱液稀释后导入电感耦合等离子体质谱系统，实现对微量元素和铀的直接分析，且操作人员与样品的相互作用降至最低。这种高效方法极大地减少了锕系元素材料中微量元素分析所需的样品体积，从而降低了成本，并符合合理可行尽量低（ALARA）原则。
