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Meeting report: 1st international conference on polyploid giant cancer cells-biology, clinical applications, and the birth of a new field in cancer research.

作者信息

Wu Tao P, Li Xiaoran, Ba Sujuan, Jones Phil, Hansel Donna E, Liu Jinsong

机构信息

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.

Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine, USA.

出版信息

Cancer Lett. 2025 Mar 1;612:217447. doi: 10.1016/j.canlet.2025.217447. Epub 2025 Jan 8.

DOI:10.1016/j.canlet.2025.217447
PMID:39793754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12186869/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/60e0d843990c/nihms-2084397-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/b9bb0e8b151e/nihms-2084397-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/bc84bbac6894/nihms-2084397-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/9812eb0177e1/nihms-2084397-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/60e0d843990c/nihms-2084397-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/b9bb0e8b151e/nihms-2084397-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/bc84bbac6894/nihms-2084397-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/9812eb0177e1/nihms-2084397-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/178a/12186869/60e0d843990c/nihms-2084397-f0004.jpg

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本文引用的文献

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Polyploid Giant Cancer Cells: A Distinctive Feature in the Transformation of Epithelial Cells by High-Risk Oncogenic HCMV Strains.多倍体巨癌细胞：高危致癌性 HCMV 株诱导上皮细胞转化的一个显著特征。
Viruses. 2024 Jul 31;16(8):1225. doi: 10.3390/v16081225.
2
Single-cell morphological and transcriptome analysis unveil inhibitors of polyploid giant breast cancer cells in vitro.单细胞形态和转录组分析揭示体外多倍体巨乳腺癌细胞的抑制剂。
Commun Biol. 2023 Dec 21;6(1):1301. doi: 10.1038/s42003-023-05674-5.
3
Cancer Associated Macrophage-like Cells Are Prognostic for Highly Aggressive Prostate Cancer in Both the Non-Metastatic and Metastatic Settings.
癌症相关巨噬细胞样细胞对非转移性和转移性高侵袭性前列腺癌均具有预后意义。
Cancers (Basel). 2023 Jul 22;15(14):3725. doi: 10.3390/cancers15143725.
4
Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer.针对多倍体巨癌细胞可增强治疗反应，并克服卵巢癌对 PARP 抑制剂的耐药性。
Sci Adv. 2023 Jul 21;9(29):eadf7195. doi: 10.1126/sciadv.adf7195.
5
The antagonistic relationship between apoptosis and polyploidy in development and cancer.凋亡与多倍体在发育和癌症中的拮抗关系。
Semin Cell Dev Biol. 2024 Mar 15;156:35-43. doi: 10.1016/j.semcdb.2023.05.009. Epub 2023 Jun 16.
6
Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells.通过多倍体巨大癌细胞的形成来观察恶性组织发生和宏观进化的时空观。
Oncogene. 2023 Feb;42(9):665-678. doi: 10.1038/s41388-022-02588-0. Epub 2023 Jan 3.
7
Monitoring PD-L1 Expression on Circulating Tumor-Associated Cells in Recurrent Metastatic Non-Small-Cell Lung Carcinoma Predicts Response to Immunotherapy With Radiation Therapy.监测复发性转移性非小细胞肺癌循环肿瘤相关细胞中的 PD-L1 表达可预测免疫治疗联合放疗的反应。
JCO Precis Oncol. 2022 Dec;6:e2200457. doi: 10.1200/PO.22.00457.
8
Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer.癌症中具有巨噬细胞样特征的循环细胞：循环肿瘤免疫杂交细胞在癌症中的重要性。
Cancers (Basel). 2022 Aug 11;14(16):3871. doi: 10.3390/cancers14163871.
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