Jin Qiqi, Lin Bin, Lu Lingfen
Department of Cardiology, Wenzhou Central Hospital, Wenzhou 325000, China.
Department of Cardiology, Wenzhou Central Hospital, Wenzhou 325000, China.
Int J Biol Macromol. 2025 Mar;296:139573. doi: 10.1016/j.ijbiomac.2025.139573. Epub 2025 Jan 8.
Dietary polysaccharides, recognised as significant natural bioactive compounds, have demonstrated promising potential for the prevention and treatment of cardiovascular disease (CVD). This review provides an overview of the biological properties and classification of polysaccharides, with particular emphasis on their extraction and purification methods. The paper then explores the diverse mechanisms by which polysaccharides exert their effects in CVD, including their antioxidant activity, protection against ischemia-reperfusion injury, anti-apoptotic properties, protection against diabetic cardiomyopathy, anticoagulant and antithrombotic effects, prevention of ventricular remodeling, and protection against vascular injury. Furthermore, this paper summarises the current status of clinical trials involving polysaccharides in CVD and analyzes the support and challenges posed by these studies for the practical application of polysaccharides. Finally, the major challenges facing the therapeutic use of polysaccharides in CVD are discussed, particularly the issues of low bioavailability and lack of standardized quality control. Through this review, we aimed to provide a reference and guidance for further research on and application of dietary polysaccharides in CVD.
膳食多糖被认为是重要的天然生物活性化合物，已显示出在预防和治疗心血管疾病（CVD）方面的潜在前景。本综述概述了多糖的生物学特性和分类，特别强调了它们的提取和纯化方法。然后本文探讨了多糖在心血管疾病中发挥作用的多种机制，包括其抗氧化活性、对缺血-再灌注损伤的保护作用、抗凋亡特性、对糖尿病性心肌病的保护作用、抗凝和抗血栓作用、预防心室重构以及对血管损伤的保护作用。此外，本文总结了涉及多糖治疗心血管疾病的临床试验现状，并分析了这些研究对多糖实际应用的支持和挑战。最后，讨论了多糖在心血管疾病治疗应用中面临的主要挑战，特别是生物利用度低和缺乏标准化质量控制的问题。通过本综述，我们旨在为膳食多糖在心血管疾病中的进一步研究和应用提供参考和指导。
