Matsuo Misaki, Cristofari Gael
Institute for Research on Cancer and Aging of Nice (IRCAN), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Cote d'Azur, Nice 06107, France
Genes Dev. 2025 Feb 3;39(3-4):183-185. doi: 10.1101/gad.352583.124.
Long interspersed element-1 (LINE-1) retrotransposons are abundant transposable elements in mammals and significantly influence chromosome structure, chromatin organization, and 3D genome architecture. In this issue of , Ataei et al. (doi:10.1101/gad.351979.124) identify a homininae-specific LINE-1 element within nucleolar organizer regions (NORs) that is specifically transcribed in naïve human embryonic stem cells. Deletion or silencing of this element disrupts nucleolar organization and function and alters cellular identity. These findings provide novel insights into the role of retrotransposons in genome organization and suggest that individual LINE-1 elements may have evolved specialized roles.
长散在核元件1（LINE-1）逆转录转座子是哺乳动物中丰富的可移动元件，对染色体结构、染色质组织和三维基因组结构有显著影响。在本期《 》中，阿塔伊等人（doi:10.1101/gad.351979.124）在核仁组织区（NORs）中鉴定出一种人亚科特异性LINE-1元件，该元件在未分化的人类胚胎干细胞中特异性转录。删除或沉默该元件会破坏核仁组织和功能，并改变细胞特性。这些发现为逆转录转座子在基因组组织中的作用提供了新的见解，并表明单个LINE-1元件可能已经进化出专门的作用。
