采用GPR75治疗肥胖症：揭示这种孤儿GPCR的已知与未知情况。
Adopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR.
作者信息
Jiang Yiao, Zhang Zhao
机构信息
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Cell Biol. 2025 Feb;35(2):102-104. doi: 10.1016/j.tcb.2024.12.006. Epub 2025 Jan 9.
Abstract
G protein-coupled receptor 75 (GPR75) is emerging as a promising target for obesity treatment, but its exact role in energy regulation remains unclear. This article explores the latest research on GPR75's molecular function, potential ligands, and therapeutic challenges in addressing obesity.
摘要
G蛋白偶联受体75（GPR75）正逐渐成为肥胖治疗的一个有前景的靶点，但其在能量调节中的具体作用仍不清楚。本文探讨了关于GPR75分子功能、潜在配体以及肥胖治疗挑战的最新研究。
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本文引用的文献
1
Ciliary localization of GPR75 promotes fat accumulation in mice.GPR75 的纤毛定位促进了小鼠脂肪的积累。
J Clin Invest. 2024 Oct 1;134(19):e185059. doi: 10.1172/JCI185059.
2
Central regulation of feeding and body weight by ciliary GPR75.通过纤毛 GPR75 对摄食和体重的中枢调节。
J Clin Invest. 2024 Aug 13;134(19):e182121. doi: 10.1172/JCI182121.
3
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation.GPR75 缺失可预防非酒精性脂肪性肝病和体脂肪堆积。
Cell Metab. 2024 May 7;36(5):1076-1087.e4. doi: 10.1016/j.cmet.2024.03.016. Epub 2024 Apr 22.
4
Gpr75 knockout mice display age-dependent cone photoreceptor cell loss.Gpr75 敲除小鼠表现出与年龄相关的视锥细胞丢失。
J Neurochem. 2023 Nov;167(4):538-555. doi: 10.1111/jnc.15979. Epub 2023 Oct 15.
5
Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.G 蛋白偶联受体 75 缺失的小鼠表现出突触前结构蛋白表达改变和恐惧条件反射记忆缺失。
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6
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