El-Adl Eman T, Ebaya Maha M, Habib El-Sayed E, Zaghloul Nadia M
Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Microbiology and Immunology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Sci Rep. 2025 Jan 10;15(1):1600. doi: 10.1038/s41598-024-78918-x.
The main objective of the current study is to compare short-term fluoride release of three ion releasing restorative materials and assess their inhibitory effect on secondary caries. Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14. For assessing secondary caries inhibition, sixty-six sound molar teeth were used and standardized class V cavities were prepared. Teeth were divided into three groups according to each material, followed by 800 cycles of thermocycling. Subsequently, teeth were immersed in a solution containing cariogenic bacteria for 30 days. After that, teeth were sectioned bucco-lingually and analyzed using a polarized light microscope to measure inhibition area, outer lesion depth, and extension. Data was statistically analyzed using different tests. The study results revealed a statistically significant differences in fluoride release existed among materials. Self-adhesive hybrid composite exhibited the highest fluoride release. Lesion extension and depth were statistically significantly greater next to Ion-releasing flowable composite liner. The inhibition areas next to the Self-adhesive hybrid composite were statistically significantly larger than the other two materials. In conclusion, all tested ion-releasing restorative materials displayed fluoride release and the potential to inhibit secondary caries formation. Self-adhesive hybrid composite demonstrated the highest fluoride-releasing potential and the greatest ability to inhibit secondary caries. Conversely, Ion-releasing flowable composite liner exhibited the least fluoride release with minimal secondary caries inhibition. Increasing fluoride release correlated with larger inhibition areas and reduced outer lesion depth and extension.
本研究的主要目的是比较三种离子释放性修复材料的短期氟释放情况，并评估它们对继发龋的抑制作用。本研究使用的材料包括自粘性混合复合材料（A组）、离子释放性可流动复合衬层（B组）和碱硅玻璃修复材料（C组）。每种材料制作22个圆盘用于短期氟释放测试，分别在第1天、第7天和第14天进行。为了评估继发龋抑制情况，使用了66颗健康磨牙并制备标准化的V类洞。根据每种材料将牙齿分为三组，然后进行800次热循环。随后，将牙齿浸泡在含有致龋菌的溶液中30天。之后，将牙齿颊舌向切片，并用偏光显微镜分析以测量抑制面积、外部病变深度和扩展情况。使用不同的测试对数据进行统计学分析。研究结果显示，材料之间的氟释放存在统计学上的显著差异。自粘性混合复合材料的氟释放量最高。在离子释放性可流动复合衬层旁边，病变扩展和深度在统计学上显著更大。自粘性混合复合材料旁边的抑制面积在统计学上显著大于其他两种材料。总之，所有测试的离子释放性修复材料都显示出氟释放以及抑制继发龋形成的潜力。自粘性混合复合材料显示出最高的氟释放潜力和最大的抑制继发龋能力。相反，离子释放性可流动复合衬层显示出最少的氟释放，对继发龋的抑制作用最小。氟释放量的增加与更大的抑制面积以及外部病变深度和扩展的减少相关。
