Gli1间充质干细胞在颅面发育和疾病治疗中的作用。
The Role of Gli1 Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment.
作者信息
Li Wen, Jiang Han, Hu Longshuang, Shen Tianjiao, Chen Qianming
机构信息
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
出版信息
J Oral Rehabil. 2025 Apr;52(4):531-539. doi: 10.1111/joor.13917. Epub 2025 Jan 10.
OBJECTIVE
This review summarises the role of Gli1 (Glioma-associated oncogene homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue repair, and their application in the treatment of some diseases.
DESIGN
The search for this narrative review was conducted in PubMed and Web of Science using relevant keywords, including checking reference lists of journal articles by hand searching.
RESULTS
Gli1 mesenchymal stem cells play an important role in the growth and development of the skull, tooth, periodontium and mandibular condyle. They can be applied to the treatment of pulp and periodontal diseases, temporomandibular joint osteoarthritis and other diseases.
CONCLUSIONS
Gli1 mesenchymal stem cells are crucial for the development and repair of craniofacial tissue.
目的
本综述总结了 Gli1（胶质瘤相关癌基因同源物 1）间充质干细胞在颅面生长发育或组织修复中的作用，及其在某些疾病治疗中的应用。
设计
通过在 PubMed 和 Web of Science 中使用相关关键词进行检索以撰写本叙述性综述，包括通过手工检索期刊文章的参考文献列表。
结果
Gli1 间充质干细胞在颅骨、牙齿、牙周组织和下颌髁突的生长发育中起重要作用。它们可应用于牙髓病和牙周病、颞下颌关节骨关节炎等疾病的治疗。
结论
Gli1 间充质干细胞对颅面组织的发育和修复至关重要。
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