Moldoveanu Claudia-Andreea, Tomoaia-Cotisel Maria, Sevastre-Berghian Alexandra, Tomoaia Gheorghe, Mocanu Aurora, Pal-Racz Csaba, Toma Vlad-Alexandru, Roman Ioana, Ujica Madalina-Anca, Pop Lucian-Cristian
Department of Molecular Biology and Biotechnology, Babeș-Bolyai University, Clinicilor St., RO-400371 Cluj-Napoca, Romania.
Department of Experimental Biology and Biochemistry, Institute of Biological Research from Cluj-Napoca, a Branch of NIRDBS Bucharest, 48 Republicii St., RO-400015 Cluj-Napoca, Romania.
Molecules. 2024 Dec 26;30(1):43. doi: 10.3390/molecules30010043.
Curcumin is among the most well-studied natural substances, known for its biological actions within the central nervous system, its antioxidant and anti-inflammatory properties, and human health benefits. However, challenges persist in effectively utilising curcumin, addressing its metabolism and passage through the blood-brain barrier (BBB) in therapies targeting cerebrovascular diseases. Current challenges in curcumin's applications revolve around its effects within neoplastic tissues alongside the development of intelligent formulations to enhance its bioavailability. Formulations have been discovered including curcumin's complexes with brain-derived phospholipids and proteins, or its liposomal encapsulation. These novel strategies aim to improve curcumin's bioavailability and stability, and its capability to cross the BBB, thereby potentially enhancing its efficacy in treating cerebrovascular diseases. In summary, this review provides a comprehensive overview of molecular pathways involved in interactions of curcumin and its metabolites, and brain vascular homeostasis. This review explores cellular and molecular current aspects, of curcumin-based effects with an emphasis on curcumin's metabolism and its impact on pathological conditions, such as neurodegenerative diseases, schizophrenia, and cerebral angiopathy. It also highlights the limitations posed by curcumin's poor bioavailability and discusses ongoing efforts to surpass these impediments to harness the full therapeutic potential of curcumin in neurological disorders.
姜黄素是研究最为深入的天然物质之一，因其在中枢神经系统中的生物活性、抗氧化和抗炎特性以及对人类健康的益处而闻名。然而，在有效利用姜黄素方面仍然存在挑战，即在针对脑血管疾病的治疗中解决其代谢及通过血脑屏障（BBB）的问题。目前姜黄素应用中的挑战主要围绕其在肿瘤组织中的作用以及开发智能制剂以提高其生物利用度。已发现的制剂包括姜黄素与脑源性磷脂和蛋白质的复合物，或其脂质体包裹物。这些新策略旨在提高姜黄素的生物利用度和稳定性，以及其穿越血脑屏障的能力，从而有可能提高其治疗脑血管疾病的疗效。总之，本综述全面概述了姜黄素及其代谢产物相互作用以及脑血管稳态所涉及的分子途径。本综述探讨了基于姜黄素作用的细胞和分子方面的当前情况，重点是姜黄素的代谢及其对神经退行性疾病、精神分裂症和脑血管病等病理状况的影响。它还强调了姜黄素生物利用度差所带来的局限性，并讨论了为克服这些障碍以充分发挥姜黄素在神经系统疾病中的治疗潜力而正在进行的努力。
