School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia, Australia.
Adv Nutr. 2018 Jan 1;9(1):41-50. doi: 10.1093/advances/nmx011.
Curcumin, from the spice turmeric, exhibits anti-inflammatory, antioxidant, anticancer, antiviral, and neurotrophic activity and therefore holds promise as a therapeutic agent to prevent and treat several disorders. However, a major barrier to curcumin's clinical efficacy is its poor bioavailability. Efforts have therefore been dedicated to developing curcumin formulations with greater bioavailability and systemic tissue distribution. However, it is proposed in this review that curcumin's potential as a therapeutic agent may not solely rely on its bioavailability, but rather its medicinal benefits may also arise from its positive influence on gastrointestinal health and function. In this review, in vitro, animal, and human studies investigating the effects of curcumin on intestinal microbiota, intestinal permeability, gut inflammation and oxidative stress, anaphylactic response, and bacterial, parasitic, and fungal infections are summarized. It is argued that positive changes in these areas can have wide-ranging influences on both intestinal and extraintestinal diseases, and therefore presents as a possible mechanism behind curcumin's therapeutic efficacy.
姜黄素是香料姜黄的主要成分，具有抗炎、抗氧化、抗癌、抗病毒和神经营养作用，因此有望成为预防和治疗多种疾病的治疗剂。然而，姜黄素临床疗效差的主要障碍是其生物利用度低。因此，人们致力于开发具有更高生物利用度和全身组织分布的姜黄素制剂。然而，在本综述中提出，姜黄素作为治疗剂的潜力可能不仅仅依赖于其生物利用度，其药用益处也可能源于其对胃肠道健康和功能的积极影响。在本综述中，总结了研究姜黄素对肠道微生物群、肠道通透性、肠道炎症和氧化应激、过敏反应以及细菌、寄生虫和真菌感染影响的体外、动物和人体研究。有人认为，这些领域的积极变化可能对肠道和肠道外疾病产生广泛影响，因此可能是姜黄素治疗功效的背后机制之一。
