基于苝二酰亚胺/氧化铜纳米材料的新型多巴胺检测电化学发光传感器。
Novel Electrochemiluminescence Sensor for Dopamine Detection Based on Perylene Diimide/CuO Nanomaterials.
作者信息
Tian Qirong, Sun Xinyang, Li Chuan, Shang Lei, Ma Rongna, Li Xiaojian, Jia Liping, He Shuijian, Zhang Qian, Zhang Wei, Wang Huaisheng
机构信息
School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.
出版信息
Molecules. 2025 Jan 5;30(1):184. doi: 10.3390/molecules30010184.
Dopamine (DA) is an important catecholamine neurotransmitter and its abnormal concentration is closely related to diseases such as hypertension, Parkinson's disease and schizophrenia. Due to the advantages of high sensitivity and fast response for electrochemiluminescence (ECL), developing ECL sensors for detecting DA was very critical in clinical diagnosis. ECL resonance energy transfer (ECL-RET) was an effective signaling mechanism. However, the shortage of highly efficient ECL-RET pairs impeded the development of DA sensors. Herein, methyl-modified perylene diimide derivative (PDI-CH) self-assembly nanorod materials as luminophores and CuO nanomaterials as acceptors were integrated into nanocomposites. An obvious ECL-RET was found in PDI-CH/CuO nanocomposites. After PDI-CH/CuO nanocomposites were treated with DA, a large increase in ECL intensity was observed. Then, PDI-CH/CuO nanocomposites were taken as an ECL platform to detect DA. This ECL sensor exhibited a linear response to DA from 10 M to 10 M with a limit of detection of 0.20 pM. Compared with other sensors for DA detection, the constructed ECL sensor exhibited higher sensitivity. In addition, the novel ECL sensor in this work showed good practicability in a human serum sample.
多巴胺（DA）是一种重要的儿茶酚胺神经递质，其浓度异常与高血压、帕金森病和精神分裂症等疾病密切相关。由于电化学发光（ECL）具有高灵敏度和快速响应的优点，开发用于检测DA的ECL传感器在临床诊断中至关重要。ECL共振能量转移（ECL-RET）是一种有效的信号传导机制。然而，高效ECL-RET对的短缺阻碍了DA传感器的发展。在此，将甲基修饰的苝二酰亚胺衍生物（PDI-CH）自组装纳米棒材料作为发光体，氧化铜纳米材料作为受体，集成到纳米复合材料中。在PDI-CH/CuO纳米复合材料中发现了明显的ECL-RET。用DA处理PDI-CH/CuO纳米复合材料后，观察到ECL强度大幅增加。然后，将PDI-CH/CuO纳米复合材料作为ECL平台来检测DA。该ECL传感器对DA在10⁻¹² M至10⁻⁶ M范围内呈现线性响应，检测限为0.20 pM。与其他用于检测DA的传感器相比，构建的ECL传感器表现出更高的灵敏度。此外，本工作中的新型ECL传感器在人血清样本中显示出良好的实用性。
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