500兆赫1H-核磁共振研究柔红霉素与d（CGm5CGCG）的B型和Z型螺旋的相互作用。
500 MHz 1H-NMR study of the interaction of daunomycin with B and Z helices of d(CGm5CGCG).
作者信息
Neumann J M, Cavailles J A, Herve M, Tran-Dinh S, Langlois d'Estaintot B, Huynh-Dinh T, Igolen J
出版信息
FEBS Lett. 1985 Mar 25;182(2):360-4. doi: 10.1016/0014-5793(85)80333-1.
PMID:3979558
Abstract
The interaction of daunomycin with B and Z helices of a self-complementary DNA fragment d(CGm5CGCG) in solution was studied by 1H-NMR spectroscopy at 500 MHz. The results show that the B-Z transition kinetics is not affected by addition of daunomycin. Daunomycin binds exclusively to the B form of d(CGm5CGCG). Z exchanges with B while the latter also exchanges with the B duplex-daunomycin complexes.
摘要
通过500兆赫的1H-核磁共振光谱研究了柔红霉素与溶液中自互补DNA片段d（CGm5CGCG）的B型和Z型螺旋的相互作用。结果表明，柔红霉素的添加不影响B-Z转变动力学。柔红霉素仅与d（CGm5CGCG）的B型结合。Z型与B型发生交换，而B型也与B双链体-柔红霉素复合物发生交换。
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