柔红霉素抑制聚 d(G-C) 中 B 型向 Z 型的转变。
Daunomycin inhibits the B leads to Z transition in poly d(G-C).
作者信息
Chaires J B
出版信息
Nucleic Acids Res. 1983 Dec 10;11(23):8485-94. doi: 10.1093/nar/11.23.8485.
Abstract
The cancer drug daunomycin is an effective inhibitor of the B leads to Z transition in poly d(G-C) in 4 M NaCl. Both the rate and extent of the B leads to Z transition are decreased by the drug, as judged by equilibrium and kinetic studies. Daunomycin can, under some conditions, convert Z form DNA back to B form. Drug binding to poly d(G-C) in 4 M NaCl is slow and highly cooperative, consistent with a role for daunomycin as an allosteric effector on the B leads to Z equilibrium. Since daunomycin binds preferentially to alternating purine-pyrimidine sequences, which are the very sequences capable of undergoing the B leads to Z transition, these effects may be an important part of the mechanism by which the drug inhibits transcription and replication.
摘要
抗癌药物柔红霉素是4M氯化钠中聚d（G-C）由B型向Z型转变的有效抑制剂。通过平衡和动力学研究判断，药物降低了B型向Z型转变的速率和程度。在某些条件下，柔红霉素可将Z型DNA转化回B型。柔红霉素在4M氯化钠中与聚d（G-C）的结合缓慢且具有高度协同性，这与柔红霉素作为B型向Z型平衡的变构效应剂的作用一致。由于柔红霉素优先结合交替的嘌呤-嘧啶序列，而这些序列正是能够发生B型向Z型转变的序列，因此这些效应可能是该药物抑制转录和复制机制的重要组成部分。
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本文引用的文献
1
[INHIBITION OF DNA-DEPENDENT RNA AND DNA SYNTHESIS BY ANTIBIOTICS].[抗生素对依赖DNA的RNA和DNA合成的抑制作用]
Biochem Z. 1964 Dec 7;341:126-8.
2
Left-handed DNA helices.左手DNA螺旋
Nature. 1980 Feb 21;283(5749):743-5. doi: 10.1038/283743a0.
3
The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.聚（dG-dC）·聚（dG-dC）的高盐形式是左手Z-DNA：晶体和溶液的拉曼光谱。
Nucleic Acids Res. 1981 Oct 24;9(20):5443-57. doi: 10.1093/nar/9.20.5443.
4
Changes in the helical repeat of poly(dG-m5dC) . poly(dG-m5dC) and poly(dG-dC) . poly(dG-dC) associated with the B-Z transition.与B-Z转变相关的聚（dG-m5dC）·聚（dG-m5dC）和聚（dG-dC）·聚（dG-dC）螺旋重复序列的变化。
Nature. 1981;293(5829):233-5. doi: 10.1038/293233a0.
5
Left-handed deoxyribonucleic acid double helix in solution.溶液中的左手螺旋脱氧核糖核酸双螺旋
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6
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