患有精子抗体的男性中自身抗体频率增加。

Increased frequency of autoantibodies in men with sperm antibodies.

作者信息

Baker H W, Clarke G N, McGowan M P, Koh S H, Cauchi M N

出版信息

Fertil Steril. 1985 Mar;43(3):438-41. doi: 10.1016/s0015-0282(16)48445-1.

Abstract

Autoantibodies to thyroid microsomes were more frequent in 102 infertile men with complement-dependent sperm-immobilizing activity (sperm immobilization test [SIT] ) in serum (11.8%) than in a control group of 277 men of comparable ages and semen quality without sperm antibodies (4.3%, P less than 0.05). Frequencies of organ-specific antibodies (antigastric parietal cell, antithyroglobulin, and antithyroid microsome) in 57 men with genital tract obstructions and positive SIT were similar to those for control subjects, and there were no significant differences in the frequencies of non-organ-specific autoantibodies (antinuclear antibody, rheumatoid factor, antimitochondrial, and anti-smooth muscle) in the three groups. Because in men without genital tract obstruction antithyroid microsomal autoantibodies were more common with sperm antibodies than without, the possibility of a genetic factor in the causation of sperm autoimmunity should be considered.

摘要

在102名血清中具有补体依赖性精子制动活性（精子制动试验[SIT]）的不育男性中，甲状腺微粒体自身抗体的出现频率（11.8%）高于277名年龄和精液质量相当但无精子抗体的对照组男性（4.3%，P<0.05）。57名生殖道梗阻且SIT阳性男性的器官特异性抗体（抗胃壁细胞、抗甲状腺球蛋白和抗甲状腺微粒体）频率与对照组相似，三组中非器官特异性自身抗体（抗核抗体、类风湿因子、抗线粒体和抗平滑肌）的频率无显著差异。由于在无生殖道梗阻的男性中，抗甲状腺微粒体自身抗体在有精子抗体的情况下比无精子抗体时更常见，因此应考虑遗传因素在精子自身免疫病因中的可能性。