Goorani Samaneh, Zangene Somaye, Imig John D
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Faculty of Medicine, University of Tehran, Tehran 1416634793, Iran.
Int J Mol Sci. 2024 Dec 26;26(1):123. doi: 10.3390/ijms26010123.
Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating disease afflicts 30-40% of the adult population worldwide. The disease burden for hypertension is great, and it greatly increases the risk of cardiovascular morbidity and mortality. Unfortunately, there are a myriad of factors that result in an elevated blood pressure. These include genetic factors, a sedentary lifestyle, obesity, salt intake, aging, and stress. Although lifestyle modifications have had limited success, anti-hypertensive drugs have been moderately effective in lowering blood pressure. New approaches to control and treat hypertension include digital health tools and compounds that activate the angiotensin receptor type 2 (AT2), which can promote cardiovascular health. Nonetheless, research on hypertension and its management is vital for lessening the significant health and economic burden of this condition.
高血压是一种由系统性血压升高所定义的心血管疾病。这种极具破坏性的疾病困扰着全球30%至40%的成年人口。高血压的疾病负担很重，它会大幅增加心血管发病和死亡的风险。不幸的是，导致血压升高的因素众多。这些因素包括遗传因素、久坐不动的生活方式、肥胖、盐摄入量、衰老和压力。尽管生活方式的改变取得的成功有限，但抗高血压药物在降低血压方面已取得一定成效。控制和治疗高血压的新方法包括数字健康工具以及激活2型血管紧张素受体（AT2）的化合物，后者可促进心血管健康。尽管如此，关于高血压及其管理的研究对于减轻这种疾病带来的重大健康和经济负担至关重要。
