Biozentrum, University of Basel, 4056 Basel, Switzerland.
Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
Science. 2023 Nov 24;382(6673):958-963. doi: 10.1126/science.abo5199. Epub 2023 Nov 23.
Adult neural stem cells (NSCs) contribute to lifelong brain plasticity. In the adult mouse ventricular-subventricular zone, NSCs are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb (OB) interneurons. Here, we show that multiple regionally distinct NSCs, including domains that are usually quiescent, are recruited on different gestation days during pregnancy. Synchronized activation of these adult NSC pools generates transient waves of short-lived OB interneurons, especially in layers with less neurogenesis under homeostasis. Using spatial transcriptomics, we identified molecular markers of pregnancy-associated interneurons and showed that some subsets are temporarily needed for own pup recognition. Thus, pregnancy triggers transient yet behaviorally relevant neurogenesis, highlighting the physiological relevance of adult stem cell heterogeneity.
成年神经干细胞 (NSC) 为大脑终生可塑性做出贡献。在成年小鼠脑室下区，NSC 具有异质性，并且根据其在小生境中的位置，产生不同类型的嗅球 (OB) 中间神经元。在这里，我们表明，包括通常处于静止状态的区域在内的多个区域不同的 NSC 会在怀孕期间的不同妊娠天数被募集。这些成年 NSC 池的同步激活会产生短暂的 OB 中间神经元的短暂波，尤其是在稳态下神经发生较少的层中。通过空间转录组学，我们鉴定了与妊娠相关中间神经元的分子标记物，并表明一些亚群暂时需要用于自身幼崽识别。因此，妊娠会引发短暂但具有行为相关性的神经发生，突出了成年干细胞异质性的生理相关性。
