Xiao Qin, Zhang Xiang, Chen Zhang-Lin, Zou Yun-Yi, Tang Chang-Fa
College of Physical Education, Hunan Normal University, Changsha 410012, China.
College of Physical Education, Hunan First Normal University, Changsha 410205, China.
Int J Mol Sci. 2025 Jan 2;26(1):332. doi: 10.3390/ijms26010332.
Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors. Exploring the pathological mechanism of myopia can provide a scientific basis for developing measures to delay the progression of myopia or even treat it. Recent advances highlight that scleral hypoxia could be an important factor in promoting myopia. In this review, we summarized the role of scleral hypoxia in the pathology of myopia and also provided interventions for myopia that target scleral hypoxia directly or indirectly. We hope this review will aid in the development of novel therapeutic strategies and drugs for myopia.
近视是全球视力损害的主要原因之一。病理性近视甚至可能导致其他严重的眼部疾病。研究人员已达成共识，近视可能由环境和遗传风险因素共同引起。探索近视的病理机制可为制定延缓近视进展甚至治疗近视的措施提供科学依据。最近的进展表明，巩膜缺氧可能是促进近视的一个重要因素。在这篇综述中，我们总结了巩膜缺氧在近视病理中的作用，并提供了直接或间接针对巩膜缺氧的近视干预措施。我们希望这篇综述将有助于开发治疗近视的新策略和药物。
