心肌梗死后基于运动的心脏康复对胆固醇向高密度脂蛋白转移的作用。

The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL.

作者信息

Nicolau Jose C, Dalcoquio Talia F, Giraldez Roberto R, Freitas Fatima R, Nicolau Andre M, Furtado Remo H M, Tavoni Thauany M, Baracioli Luciano M, Lima Felipe G, Ferrari Aline G, Rondon Maria U P B, Salsoso Rocio, Alves Maria J N N, Arantes Flavia B B, Santos Mayara A, Alves Leandro S, Negrao Carlos E, Maranhão Raul C

机构信息

Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-220, SP, Brazil.

Hospital Sírio-Libanês, São Paulo 01308-050, SP, Brazil.

出版信息

Int J Mol Sci. 2025 Jan 6;26(1):419. doi: 10.3390/ijms26010419.

DOI:10.3390/ijms26010419

PMID:39796273

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11720861/

Abstract

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understood. Sixty-two patients with acute MI were randomized in a supervised exercise program for 12-14 weeks (exercise group-EG) or a control group (CG). The main objective of the study was to analyze the role of exercise on esterified cholesterol (EC) and unesterified cholesterol (UC) transfer to HDL. For the total population, the baseline mean rate of EC transfer to HDL was 2.53 ± 0.83 and at the end of follow-up, it was 2.74 ± 0.64 ( = 0.03). The figures for UC were, respectively, 4.08 ± 1.2 and 4.4 ± 1.06 ( = 0.02). The difference (follow-up minus baseline) for EC was 0.15 ± 0.84 for the control group and 0.27 ± 0.69 for the exercise group ( = 0.53); for UC, the figures were 0.28 ± 1.14 and 0.35 ± 0.96 ( = 0.80), respectively, for the control and exercise groups. In post-MI patients, 12-14 weeks of supervised exercise did not improve HDL functionality.

摘要

高密度脂蛋白（HDL）与心血管事件发生率降低相关，其功能也会影响预后。运动是改善心肌梗死（MI）后人群预后的重要手段，但运动对HDL功能的作用尚不清楚。62例急性心肌梗死患者被随机分为接受12 - 14周有监督运动计划的运动组（EG）或对照组（CG）。该研究的主要目的是分析运动对酯化胆固醇（EC）和未酯化胆固醇（UC）向HDL转移的作用。对于总体人群，EC向HDL转移的基线平均速率为2.53±0.83，随访结束时为2.74±0.64（P = 0.03）。UC的相应数据分别为4.08±1.2和4.4±1.06（P = 0.02）。对照组EC的差异（随访减去基线）为0.15±0.84，运动组为0.27±0.69（P = 0.53）；对于UC，对照组和运动组的数据分别为0.28±1.14和0.35±0.96（P = 0.80）。在心肌梗死后患者中，12 - 14周的有监督运动并未改善HDL功能。