Pierard G E, Pierard-Franchimont C, Lapière C M
Dermatologica. 1985;170(3):105-13.
A combined histological and biomechanical study was performed in patients with localised or systemic scleroderma. The inflammatory reaction was variable in intensity and location, predominating around the superficial vascular plexus, the deep dermo-hypodermal plexus, the paraseptal plexus or in the fasciae. Secondary sclerosis resulted from the lateral fusion of bundles of collagen fibers. Three degrees of intensity of sclerosis were disclosed by our noninvasive technique of tonometry by vertical traction of the skin in vivo. That measurement allowed a follow-up of the evolution of the disease and a control of the therapeutic efficacy.
对局限性或系统性硬皮病患者进行了组织学和生物力学联合研究。炎症反应在强度和位置上存在差异，主要集中在浅表血管丛、深部真皮 - 皮下丛、隔旁丛或筋膜中。继发性硬化是由胶原纤维束的侧向融合导致的。我们通过在体内垂直牵引皮肤的眼压测量无创技术揭示了三种硬化强度程度。该测量方法能够对疾病的进展进行随访并评估治疗效果。
