饮食中铁摄入量与吸烟所致精神和行为障碍：一项英国生物银行研究。
Dietary Iron Intake and Mental and Behavioral Disorders Due to Use of Tobacco: A UK Biobank Study.
作者信息
Qi Xueting, Zhang Ronghui, Zhu Hailong, Luo Jia, Zhang Qiuge, Wang Weijing, Wang Tong, Zhang Dongfeng
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.
Department of Operations Management, Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
出版信息
Nutrients. 2024 Dec 26;17(1):39. doi: 10.3390/nu17010039.
BACKGROUND
Over 1 billion smokers worldwide, one-third of whom have mental and behavioral disorders, exist. However, factors influencing mental and behavioral disorders due to the use of tobacco remain largely unexplored. This study aims to investigate the relationship between dietary iron intake and mental and behavioral disorders due to the use of tobacco.
METHODS
Using large population cohort data from the UK Biobank (500,000 participants at 22 assessment centers between 2006 and 2010), we employed logistic and Cox regression analyses to explore both cross-sectional and longitudinal associations between dietary iron intake and mental and behavioral disorders due to the use of tobacco. Additionally, we assessed the nonlinear relationship between dietary iron intake and these disorders using restricted cubic spline plots.
RESULTS
Logistic regression analysis indicated that dietary iron intake was negatively associated with mental and behavioral disorders due to the use of tobacco. The Cox regression results supported a protective effect of increased dietary iron intake against these disorders. Stratified and sensitivity analyses were consistent with the primary findings. Restricted cubic spline plots revealed a nonlinear relationship between dietary iron intake and mental and behavioral disorders due to the use of tobacco. In the total sample, as well as in both age groups and the male subgroup, the risk reduction rate initially accelerated before slowing down. In contrast, the risk reduction rate in the female group declined rapidly at first and then leveled off.
CONCLUSIONS
This study demonstrates that dietary iron intake has a protective effect against mental and behavioral disorders due to the use of tobacco, revealing a nonlinear association between these two traits. These findings provide important insights for the profilaxy and treatment of mental and behavioral disorders due to the use of tobacco in the future.
背景
全球有超过10亿吸烟者，其中三分之一患有精神和行为障碍。然而，烟草使用导致精神和行为障碍的影响因素在很大程度上仍未得到探索。本研究旨在调查膳食铁摄入量与烟草使用所致精神和行为障碍之间的关系。
方法
利用英国生物银行的大规模人群队列数据（2006年至2010年间在22个评估中心的50万名参与者），我们采用逻辑回归和Cox回归分析来探讨膳食铁摄入量与烟草使用所致精神和行为障碍之间的横断面和纵向关联。此外，我们使用受限立方样条图评估了膳食铁摄入量与这些障碍之间的非线性关系。
结果
逻辑回归分析表明，膳食铁摄入量与烟草使用所致精神和行为障碍呈负相关。Cox回归结果支持增加膳食铁摄入量对这些障碍具有保护作用。分层分析和敏感性分析与主要发现一致。受限立方样条图显示膳食铁摄入量与烟草使用所致精神和行为障碍之间存在非线性关系。在总样本以及两个年龄组和男性亚组中，风险降低率最初加速，然后放缓。相比之下，女性组的风险降低率起初迅速下降，然后趋于平稳。
结论
本研究表明，膳食铁摄入量对烟草使用所致精神和行为障碍具有保护作用，揭示了这两个特征之间的非线性关联。这些发现为未来烟草使用所致精神和行为障碍的预防和治疗提供了重要见解。
Zotero 插件