Salvado Rita, Lugones-Sánchez Cristina, Santos-Minguez Sandra, González-Sánchez Susana, Quesada José A, Benito Rocío, Rodríguez-Sánchez Emiliano, Gómez-Marcos Manuel A, Guimarães-Cunha Pedro, Hernandez-Rivas Jesús M, Mira Alex, García-Ortiz Luis
Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), 37005 Salamanca, Spain.
Nutrients. 2024 Dec 27;17(1):53. doi: 10.3390/nu17010053.
Recent research highlights the potential role of sex-specific variations in cardiovascular disease. The gut microbiome has been shown to differ between the sexes in patients with cardiovascular risk factors.
The main objective of this study is to analyze the differences between women and men in the relationship between gut microbiota and measures of arterial stiffness.
We conducted a cross-sectional study in Spain, selecting 180 subjects (122 women, 58 men) aged between 45 and 74. Subjects with arterial stiffness were identified by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV) above 12 mm/s, cardio-ankle vascular index (CAVI) above nine, or brachial-ankle pulse wave velocity (ba-PWV) above 17.5 m/s. All other cases were considered subjects without arterial stiffness. The composition of the gut microbiome in fecal samples was determined by 16S rRNA sequencing.
We found that women have a more diverse microbiome than men (Shannon, < 0.05). There is also a significant difference in gut microbiota composition between sexes (Bray-Curtis, < 0.01). , and all of them short-chain fatty-acid producers, were more abundant in women's microbiota (log values > 1, -value and FDR < 0.05). Additionally, was more abundant in women when only the subjects with arterial stiffness were considered. According to logistic regression, was negatively associated with arterial stiffness in men, while and were positively related to arterial stiffness.
In the Spanish population under study, women had higher microbiome diversity and potentially protective genera. The host's gender determines the influence of the same bacteria on arterial stiffness.
NCT03900338.
近期研究凸显了心血管疾病中性别特异性差异的潜在作用。在有心血管危险因素的患者中，肠道微生物群已显示出性别差异。
本研究的主要目的是分析肠道微生物群与动脉僵硬度指标之间关系在女性和男性中的差异。
我们在西班牙进行了一项横断面研究，选取了180名年龄在45至74岁之间的受试者（122名女性，58名男性）。通过以下至少一项指标来确定有动脉僵硬度的受试者：颈股脉搏波速度（cf-PWV）高于12毫米/秒、心踝血管指数（CAVI）高于9或臂踝脉搏波速度（ba-PWV）高于17.5米/秒。所有其他病例被视为无动脉僵硬度的受试者。通过16S rRNA测序确定粪便样本中肠道微生物群的组成。
我们发现女性的微生物群比男性更多样化（香农指数，<0.05）。性别之间的肠道微生物群组成也存在显著差异（布雷-柯蒂斯指数，<0.01）。 ，它们都是短链脂肪酸产生菌，在女性微生物群中更为丰富（对数数值>1，-值和FDR<0.05）。此外，仅考虑有动脉僵硬度的受试者时， 在女性中更为丰富。根据逻辑回归分析， 在男性中与动脉僵硬度呈负相关，而 和 与动脉僵硬度呈正相关。
在所研究的西班牙人群中，女性具有更高的微生物群多样性和潜在的保护性菌属。宿主性别决定了相同细菌对动脉僵硬度的影响。
NCT03900338。
