Messika Amalia, Toledano Yoel, Hadar Eran, Tauman Riva, Froy Oren, Shamir Raanan
Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel.
Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Nutrients. 2024 Dec 31;17(1):157. doi: 10.3390/nu17010157.
BACKGROUND/OBJECTIVES: Studies have shown that chronobiological factors may adversely affect glycemic control in patients with type 2 diabetes mellitus. We assessed the association of chronobiological factors with glycemic control and neonatal birth weight in women with GDM.
A prospective cohort study included 208 women aged 18-45 years with a singleton pregnancy who were randomly selected from among women undergoing follow-up for GDM at the Maternal-Fetal Medicine Unit of a tertiary medical center. Nutrition, sleep, and lifestyle patterns were assessed from onset of GDM until birth along with glycemic control and birth outcomes.
Multivariate analyses on a cohort of 208 women revealed that suboptimal glycemic control was associated with a late breakfast (RR = 2.26; 95% CI 1.09-4.67), increased carbohydrate intake in the evening (RR = 1.19; 95% CI 1.003-1.42), and poor sleep quality (RR = 2.14; 95% CI 1.04-4.41). The adjusted relative risk for neonatal birth weight above the 85th percentile was associated with increased carbohydrate intake in the morning (RR = 1.70; 95% CI 1.30-2.23) and increased carbohydrate intake in the evening (RR = 1.39; 95% CI 1.16-1.67).
Chronobiological factors are associated with suboptimal glycemic control and birth weight above the 85th percentile in women with GDM. The study was registered under ClinicalTrials.gov.org, identifier: NCT02916667.
背景/目的：研究表明，生物钟因素可能会对2型糖尿病患者的血糖控制产生不利影响。我们评估了生物钟因素与妊娠期糖尿病（GDM）女性的血糖控制及新生儿出生体重之间的关联。
一项前瞻性队列研究纳入了208名年龄在18至45岁之间、单胎妊娠的女性，这些女性是从一家三级医疗中心的母胎医学科接受GDM随访的女性中随机选取的。从GDM发病至分娩期间，对营养、睡眠和生活方式模式进行了评估，同时评估了血糖控制情况和分娩结局。
对208名女性队列进行的多变量分析显示，血糖控制不佳与早餐时间晚（风险比[RR]=2.26；95%置信区间[CI]1.09 - 4.67）、晚餐碳水化合物摄入量增加（RR = 1.19；95% CI 1.003 - 1.42）以及睡眠质量差（RR = 2.14；95% CI 1.04 - 4.41）有关。新生儿出生体重高于第85百分位数的校正相对风险与早餐碳水化合物摄入量增加（RR = 1.70；95% CI 1.30 - 2.23）和晚餐碳水化合物摄入量增加（RR = 1.39；95% CI 1.16 - 1.67）有关。
生物钟因素与GDM女性血糖控制不佳及出生体重高于第85百分位数有关。该研究已在ClinicalTrials.gov.org上注册，标识符：NCT02916667。
