CICS-UBI-Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal.
Unidade de Investigação para o Desenvolvimento do Interior (UDI-IPG), Instituto Politécnico da Guarda, Guarda, Portugal.
J Cell Physiol. 2022 Aug;237(8):3239-3256. doi: 10.1002/jcp.30815. Epub 2022 Jun 13.
The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental to autoimmune diseases, and with life quality change. Following this, some therapies have been developed to correct circadian misalignments, such as light therapy and chronobiotics. In this manuscript, we describe the circadian-related diseases so far investigated, and studies reporting relevant data on this topic, evidencing this relationship, are included. Despite the actual limitations in published work, there is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and, in this way, clock-related therapies emerge as great progress in the clinical field. Future improvements in such interventions can lead to the development of successful chronotherapy strategies, deeply contributing to enhanced therapeutic outcomes.
生物钟系统负责根据环境线索（zeitgebers）对机体的内部功能和调节。生物钟节律失调或生物钟紊乱与多种疾病有关，从精神疾病到自身免疫性疾病，以及生活质量的变化。因此，已经开发了一些疗法来纠正生物钟的偏差，例如光疗法和时间生物学疗法。在本文中，我们描述了迄今为止研究过的与生物钟相关的疾病，并纳入了报告该主题相关数据的研究，证明了这种相关性。尽管在已发表的研究中存在实际限制，但生物钟节律失调与疾病起源/发展之间的相关性有明确的证据，因此，与时钟相关的治疗方法作为临床领域的重大进展而出现。这种干预措施的未来改进可以导致成功的时间治疗策略的发展，这将极大地有助于提高治疗效果。
