Dong Yihao, Zhang Qinchun, Xie Rui, Zhao Jundi, Han Zhihua, Li Yu, Yu Han, Zhang Yongfeng
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China.
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Nutrients. 2024 Dec 31;17(1):160. doi: 10.3390/nu17010160.
Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is a significant contributor to the onset of the development of cardiovascular disease. Berk contains various active ingredients that have anti-inflammatory, antioxidant, and hypolipidemic properties. Nevertheless, the potential effects of on atherosclerosis have not been systematically reported.
In this study, ApoE mice were employed as models of atherosclerosis caused by a high-fat diet (HFD) to investigate the effect of . Gut microbiota and serum metabolism analysis were performed to elucidate the potential mechanism of for its anti-atherosclerosis effects.
significantly decreased the aortic root wall thickness and the area of lipid droplets, regulated lipid levels, and inhibited fat accumulation to improve aortic root lesions. Furthermore, significantly altered serum metabolite (including diethyl phthalate and succinate) levels, regulated the abundance of microbiota, such as and , and suppressed the inflammatory response to ameliorate atherosclerosis via the nuclear factor-kappa B (NF-κB)-mediated inflammatory response in HFD-induced ApoE mice.
These results offer a theoretical basis and data to support as a potential strategy for treating atherosclerosis.
动脉粥样硬化是一种以动脉粥样硬化斑块或纤维斑块为特征的持续性炎症性疾病，是心血管疾病发生发展的重要促成因素。伯克含有多种具有抗炎、抗氧化和降血脂特性的活性成分。然而，其对动脉粥样硬化的潜在影响尚未有系统报道。
在本研究中，将载脂蛋白E（ApoE）小鼠用作高脂饮食（HFD）诱导的动脉粥样硬化模型，以研究其作用效果。进行肠道微生物群和血清代谢分析，以阐明其抗动脉粥样硬化作用的潜在机制。
显著降低主动脉根部壁厚度和脂滴面积，调节血脂水平，抑制脂肪堆积，改善主动脉根部病变。此外，显著改变血清代谢物（包括邻苯二甲酸二乙酯和琥珀酸）水平，调节微生物群的丰度，如和，并通过抑制高脂饮食诱导的ApoE小鼠中核因子-κB（NF-κB）介导的炎症反应来减轻炎症反应，从而改善动脉粥样硬化。
这些结果为支持将其作为治疗动脉粥样硬化的潜在策略提供了理论依据和数据。
