Gao Zhan-Kui, Fan Chao-Yuan, Zhang Bo-Wen, Geng Jia-Xin, Han Xing, Xu Dan-Qi, Arshad Muhammad, Sun Hao-Xuan, Li Jiong-Yi, Jin Xiangyuan, Mu Xiao-Qin
Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province), College of Pharmacy, Harbin Medical University, Harbin, 150081, China.
National Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, 150081, China.
Anim Microbiome. 2025 May 30;7(1):53. doi: 10.1186/s42523-025-00405-z.
Several studies have indicated that the dysregulation of microbial metabolites and the inflammatory environment resulting from microbial dysbiosis may contribute to the occurrence and progression of cardiovascular diseases. Therefore, restoring the disordered gut microbiota in patients with colorectal cancer by fecal microbiota transplantation (FMT) has the potential to reduce the incidence of cardiac disease. In this study, we identified cardiac dysfunction in azomethane and dextran sodium sulfate-induced colorectal cancer mice. Intestinal microbes from healthy mice were transferred to colorectal cancer mice, which vastly reversed the disorder of the gut microbiota and effectively alleviated cardiac dysfunction. Moreover, FMT regulated the expression of serum metabolites such as uridine triphosphate (UTP), tiamulin, andrographolide, and N-Acetyl-D-glucosamine, as well as cytokines like TGF-β, IRF5, and β-MHC in the heart. These findings uncover that the disturbed gut microbiota causes cardiac dysfunction in colorectal cancer mice by modulating the expression of serum metabolites and cytokines, which could be alleviated by treatment with FMT.
多项研究表明，微生物代谢产物的失调以及微生物群落失衡所导致的炎症环境可能促使心血管疾病的发生与发展。因此，通过粪便微生物群移植（FMT）恢复结直肠癌患者紊乱的肠道微生物群，有可能降低心脏病的发病率。在本研究中，我们在接受偶氮甲烷和葡聚糖硫酸钠诱导的结直肠癌小鼠中发现了心脏功能障碍。将健康小鼠的肠道微生物转移至结直肠癌小鼠体内，这极大地逆转了肠道微生物群的紊乱，并有效缓解了心脏功能障碍。此外，FMT调节了心脏中血清代谢产物如三磷酸尿苷（UTP）、泰妙菌素、穿心莲内酯和N-乙酰-D-葡萄糖胺的表达，以及细胞因子如转化生长因子-β（TGF-β）、干扰素调节因子5（IRF5）和β-肌球蛋白重链（β-MHC）的表达。这些发现揭示，肠道微生物群紊乱通过调节血清代谢产物和细胞因子的表达导致结直肠癌小鼠出现心脏功能障碍，而FMT治疗可缓解这种情况。
