Duszkiewicz Roksana, Strzelczyk Janusz, Chełmecka Elżbieta, Strzelczyk Joanna Katarzyna
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana St., 41-808 Zabrze, Poland.
Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia 35 Ceglana St., 40-514 Katowice, Poland.
Cancers (Basel). 2024 Dec 27;17(1):47. doi: 10.3390/cancers17010047.
Neuroendocrine tumors are a diverse group of tumors predominantly found in the gastrointestinal tract or respiratory system. : This retrospective study aimed to measure the serum concentrations of LRP6 (low-density lipoprotein receptor-related protein 6), SFRP3 (secreted frizzled-related protein 3), and DVL1 (segment polarity protein dishevelled homolog) using the ELISA method in patients with NETs (N = 80) and a control group (N = 62). We evaluated the results against various demographic, clinicopathological, and biochemical characteristics. : Our analyses revealed that the concentration of SFRP3 in patients with neuroendocrine tumors was significantly elevated ( < 0.001) compared to the control group. Additionally, DVL1 concentrations were significantly higher ( < 0.01) in patients with BP-NETs compared to GEP-NETs. Furthermore, DVL1 analysis showed a moderate negative correlation with chromogranin A ( < 0.001) and weak negative correlations with serotonin ( < 0.05) and 5-HIAA ( < 0.05). Significant negative correlations were also observed between DVL1 and age in the control group ( < 0.01), and between LRP6 and Ki-67 in the study group. These results suggest that changes in the SFRP3 and DVL1 pathways play a key role in NET development. Elevated levels of these proteins highlight their importance in tumor biology, with SFRP3 and DVL1 potentially being crucial in NET molecular mechanisms. Further research is needed to explore their roles and potential in diagnosis and treatment.
神经内分泌肿瘤是一组主要发生在胃肠道或呼吸系统的多种肿瘤。本回顾性研究旨在采用酶联免疫吸附测定（ELISA）法测量80例神经内分泌肿瘤（NETs）患者和62例对照组患者血清中低密度脂蛋白受体相关蛋白6（LRP6）、分泌型卷曲相关蛋白3（SFRP3）和段极性蛋白蓬乱同系物1（DVL1）的浓度。我们根据各种人口统计学、临床病理和生化特征评估了结果。我们的分析显示，与对照组相比，神经内分泌肿瘤患者的SFRP3浓度显著升高（<0.001）。此外，与胃肠胰神经内分泌肿瘤（GEP-NETs）相比，支气管肺神经内分泌肿瘤（BP-NETs）患者的DVL1浓度显著更高（<0.01）。此外，DVL1分析显示与嗜铬粒蛋白A呈中度负相关（<0.001），与血清素（<0.05）和5-羟吲哚乙酸（<0.05）呈弱负相关。在对照组中，DVL1与年龄之间也观察到显著负相关（<0.01），在研究组中，LRP6与Ki-67之间也观察到显著负相关。这些结果表明，SFRP3和DVL1信号通路的变化在神经内分泌肿瘤的发生发展中起关键作用。这些蛋白质水平的升高突出了它们在肿瘤生物学中的重要性，SFRP3和DVL1可能在神经内分泌肿瘤的分子机制中起关键作用。需要进一步研究以探索它们在诊断和治疗中的作用及潜力。
