Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Stem Cell Rev Rep. 2024 Jan;20(1):52-66. doi: 10.1007/s12015-023-10610-5. Epub 2023 Oct 7.
Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is compensated by generating new cells with the capacity for proliferation and differentiation. At the origin of these populations are the stem cells, which have the potential to give rise to cells with both capabilities, and persevere for a long time through the self-renewal and quiescence. Since the discovery of stem cells, an enormous effort has been focused on learning about their functions and the molecular regulation behind them. Wnt signaling is widely recognized as essential for normal and cancer stem cell. Moreover, β-catenin-dependent Wnt pathway, referred to as canonical, has gained attention, while β-catenin-independent Wnt pathways, known as non-canonical, have remained conspicuously less explored. However, recent evidence about non-canonical Wnt pathways in stem cells begins to lay the foundations of a conceivably vast field, and on which we aim to explain this in the present review. In this regard, we addressed the different aspects in which non-canonical Wnt pathways impact the properties of stem cells, both under normal conditions and also under disease, specifically in cancer.
组织稳态对于多细胞生物至关重要，其中细胞的损失通过生成具有增殖和分化能力的新细胞来补偿。这些细胞群体起源于干细胞，它们具有产生具有这两种能力的细胞的潜力，并通过自我更新和静止而长期存在。自干细胞发现以来，人们已经付出了巨大的努力来了解它们的功能及其背后的分子调控。Wnt 信号通路被广泛认为对正常和癌症干细胞至关重要。此外，β-连环蛋白依赖性 Wnt 途径，称为经典途径，已引起关注，而β-连环蛋白非依赖性 Wnt 途径，称为非经典途径，仍然明显研究较少。然而，最近关于干细胞中非经典 Wnt 途径的证据开始为一个可以想象的广阔领域奠定基础，我们旨在在本综述中解释这一点。在这方面，我们讨论了非经典 Wnt 途径在正常和疾病条件下（特别是在癌症中）影响干细胞特性的不同方面。
