神经内分泌肿瘤骨转换的选定参数——有潜在临床用途吗？

Selected Parameters of Bone Turnover in Neuroendocrine Tumors-A Potential Clinical Use?

作者信息

Strzelczyk Janusz, Wójcik-Giertuga Monika, Strzelczyk Joanna Katarzyna, Seńkowska Alicja Prawdzic, Biernacki Krzysztof, Kos-Kudła Beata

机构信息

Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 35 Ceglana St., 40-514 Katowice, Poland.

Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana St., 41-808 Zabrze, Poland.

出版信息

J Clin Med. 2023 Jul 11;12(14):4608. doi: 10.3390/jcm12144608.

DOI:10.3390/jcm12144608

PMID:37510722

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10380215/

Abstract

BACKGROUND

Currently, there are no effective markers to diagnose and monitor patients with neuroendocrine tumors (NETs). The aim of this study was to assess bone metabolism based on selected markers of bone turnover: OST, OPG, and IGFBP-3, in both the group of patients with NETs and the control group. Associations with selected sociodemographic, biochemical, and clinicopathological characteristics were examined. We also evaluated any potential associations between these markers and selected biochemical markers of NETs commonly used in clinical practice.

METHODS

The study group included 60 patients with GEP-NETs and BP-NETs, while the control group comprised 62 healthy individuals. The serum concentrations of OST, OPG and IGFBP-3 were assessed using ELISA.

RESULTS

OST and OPG levels were significantly higher in the study group compared to the control group. In the study group, we observed a significant correlation between OPG and the clinical stage and chromogranin A. Additionally, an association was found between OPG and histological grade, Ki-67, and metastasis in GEP-NET cases.

CONCLUSIONS

Markers of bone turnover cannot be used in the routine diagnostics of neuroendocrine tumors. Nonetheless, these markers may help evaluate the skeletal system in patients with NETs. Further research is needed to determine the utility of osteocalcin (OST) and osteoprotegerin (OPG) as potential biomarkers for neuroendocrine tumors.

摘要

背景

目前，尚无有效的标志物用于诊断和监测神经内分泌肿瘤（NETs）患者。本研究的目的是基于骨转换的选定标志物：骨钙素（OST）、骨保护素（OPG）和胰岛素样生长因子结合蛋白-3（IGFBP-3），对NETs患者组和对照组的骨代谢进行评估。研究了这些标志物与选定的社会人口统计学、生化和临床病理特征之间的关联。我们还评估了这些标志物与临床实践中常用的NETs选定生化标志物之间的潜在关联。