Matta Rita, Balogh-Lantos Zsofia, Fekete Zoltan, Baca Martin, Kaszas Attila, Moreau David, O'Connor Rodney Philip
Mines Saint-Etienne, Centre CMP, Département BEL, F-13541 Gardanne, France.
Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pazmany Peter Catholic University, H-1083 Budapest, Hungary.
Sensors (Basel). 2024 Dec 24;25(1):4. doi: 10.3390/s25010004.
The primary method of treatment for patients suffering from drug-resistant focal-onset epilepsy is resective surgery, which adversely impacts neurocognitive function. Radio frequency (RF) ablation and laser ablation are the methods with the most promise, achieving seizure-free rates similar to resection but with less negative impact on neurocognitive function. However, there remains a number of concerns and open technical questions about these two methods of thermal ablation, with the primary ones: (1) heating; (2) hemorrhage and bleeding; and (3) poor directionality. Irreversible electroporation (IRE) is a proven method of focal ablation, which circumvents all three of the primary concerns regarding focal RF and laser ablation. Here, we demonstrate the in vivo application of a flexible implant with organic electrodes for focal ablation of epilepsy foci using high-frequency IRE (H-FIRE) in mice. Our results show that local, targeted ablation is possible in the close neighborhood of the electrode, paving the way for the clinical application in the treatment of focal epilepsy.
对于耐药性局灶性癫痫患者，主要的治疗方法是切除性手术，但这会对神经认知功能产生不利影响。射频（RF）消融和激光消融是最有前景的方法，其实现无癫痫发作率与切除术相似，但对神经认知功能的负面影响较小。然而，对于这两种热消融方法仍存在一些担忧和尚未解决的技术问题，主要包括：（1）加热；（2）出血；（3）方向性差。不可逆电穿孔（IRE）是一种已被证实的局灶性消融方法，它规避了与局灶性射频和激光消融相关的所有三个主要问题。在此，我们展示了一种带有有机电极的柔性植入物在小鼠体内使用高频不可逆电穿孔（H-FIRE）对局灶性癫痫病灶进行消融的应用。我们的结果表明，在电极附近进行局部、靶向消融是可行的，为局灶性癫痫治疗的临床应用铺平了道路。
