Skórka Mateusz, Bazaliński Dariusz, Więch Paweł, Kłęk Stanisław, Kozieł Dorota, Sierżantowicz Regina
St. Luke's Regional Hospital, Independent Community Health Care Centre, 33-100 Tarnów, Poland.
Institute of Health Sciences, College of Medical Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
J Clin Med. 2024 Dec 25;14(1):43. doi: 10.3390/jcm14010043.
Wound healing is a complex physiological process that begins immediately upon injury. Nutritional status significantly affects the course of regenerative processes. Malnutrition can prolong the inflammatory phase, limit collagen synthesis, and increase the risk of new wound formation. The issue of malnutrition is becoming increasingly prevalent and remains a significant concern, particularly among older adults dealing with chronic conditions. : The study was conducted at the Wound Treatment Clinic of the Specialist Hospital at the Podkarpackie Oncology Center in Brzozów, Poland, over 12 months (31 December 2022 to 31 December 2023). A prospective assessment was carried out on 106 patients with chronic wounds. The sample selection was purposeful, based on the following criteria: individuals with hard-to-heal vascular wounds related to diabetic foot disease or venous insufficiency, who provided informed consent to participate after reviewing the study concept. The assessment included a questionnaire and biochemical blood analysis. Further evaluations covered wound characteristics and classification based on clinical scales. The morphotic and biochemical blood parameter assessment included albumin concentration, hemoglobin, C-reactive protein (CRP), and the nutritional risk index (NRI). : A larger wound area was associated with lower morphotic values in both groups. Exudate levels and severity in chronic venous insufficiency (CVI) patients and diabetic foot disease (DFD) were associated with lower hemoglobin, albumin, and NRI values. At the same time, the depth of tissue structure damage correlated with the measured biochemical parameters. : NRI values and morphotic blood parameters, along with albumin, hemoglobin, and CRP levels, are closely associated with wound characteristics, including surface area, exudate level, and the severity of tissue destruction. The greater the destruction of tissue structures, the higher the risk of malnutrition and wound infection, as indicated by biochemical assessment.
伤口愈合是一个复杂的生理过程，在受伤后立即开始。营养状况会显著影响再生过程的进程。营养不良会延长炎症期、限制胶原蛋白合成，并增加新伤口形成的风险。营养不良问题日益普遍，仍然是一个重大问题，尤其是在患有慢性病的老年人中。：该研究在波兰布罗佐夫市波德卡尔帕茨肿瘤中心专科医院的伤口治疗诊所进行，为期12个月（2022年12月31日至2023年12月31日）。对106例慢性伤口患者进行了前瞻性评估。样本选择是有目的的，基于以下标准：患有与糖尿病足病或静脉功能不全相关的难愈合血管伤口的个体，他们在审查研究概念后提供了知情同意书参与研究。评估包括问卷调查和血液生化分析。进一步的评估涵盖基于临床量表的伤口特征和分类。形态学和血液生化参数评估包括白蛋白浓度、血红蛋白、C反应蛋白（CRP）和营养风险指数（NRI）。：两组中，较大的伤口面积与较低的形态学值相关。慢性静脉功能不全（CVI）患者和糖尿病足病（DFD）患者的渗出液水平和严重程度与较低的血红蛋白、白蛋白和NRI值相关。同时，组织结构损伤的深度与所测量的生化参数相关。：NRI值和形态学血液参数，以及白蛋白、血红蛋白和CRP水平，与伤口特征密切相关，包括表面积、渗出液水平和组织破坏的严重程度。生化评估表明，组织结构破坏越严重，营养不良和伤口感染的风险越高。
