Taormina Antonio, Grossi Benedetta, Ragaini Elisa Maria, Falasconi Giulio, Penela Diego, Ceriotti Carlo, Poggio Luca, Galimberti Paola, Latini Alessia Chiara, Carli Sebastiano, Del Monaco Guido, Chiarito Mauro, Sticchi Alessandro, Giunti Filippo, Antonelli Giulia, Preda Alberto, Guarracini Fabrizio, Mazzone Patrizio, Condorelli Gianluigi
Cardiac Arrhythmia Department, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, 6, 20089 Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy.
J Clin Med. 2024 Dec 29;14(1):130. doi: 10.3390/jcm14010130.
Pulmonary vein isolation (PVI) represents the cornerstone of paroxysmal (PAF) and persistent atrial fibrillation (PsAF) ablation. Impedance values provide insights on tissue conductive properties. Consecutive patients undergoing PAF and PsAF ablation were prospectively enrolled. All the patients underwent a preprocedural multidetector computed tomography (MDCT) to evaluate left atrial wall thickness (LAWT). Electroanatomic maps were acquired with the ablation catheter, and impedance values (Ω) and voltage amplitude (mV) of bipolar electrograms were collected. A total of 60 patients (40 with PAF and 20 with PsAF) were included in the study. In all PAF cases, no voltage value lower than 0.5 mV was found at LA mapping; the corresponding mean impedance value was 151.5 ± 5.4 Ω. In PsAF cases, voltage values inferior to 0.05 mV have been reported in 19/20 patients. PsAF patients showed a mean impedance value of 129.1 ± 3.8 Ω. The correlation analysis between bipolar voltage and impedance reported an r value of 0.4166 ( < 0.001), showing a positive correlation between the two variables. On the contrary, no direct correlation was found between voltage and LAWT and between impedance and LAWT (rsv-t = 0.1838; rsi-t = 0.1133, respectively). This research study suggests a correlation between voltage amplitude and impedance values, so that impedance might be used for arrhythmogenic substrate characterization.
肺静脉隔离（PVI）是阵发性房颤（PAF）和持续性房颤（PsAF）消融的基石。阻抗值可提供有关组织传导特性的见解。前瞻性纳入了连续接受PAF和PsAF消融的患者。所有患者均接受术前多排螺旋计算机断层扫描（MDCT）以评估左心房壁厚度（LAWT）。使用消融导管获取电解剖图，并收集双极电图的阻抗值（Ω）和电压幅度（mV）。本研究共纳入60例患者（40例PAF患者和20例PsAF患者）。在所有PAF病例中，左心房标测时未发现电压值低于0.5 mV；相应的平均阻抗值为151.5±5.4Ω。在PsAF病例中，20例患者中有19例报告电压值低于0.05 mV。PsAF患者的平均阻抗值为129.1±3.8Ω。双极电压与阻抗之间的相关性分析显示r值为0.4166（<0.001），表明这两个变量之间呈正相关。相反，未发现电压与LAWT之间以及阻抗与LAWT之间存在直接相关性（分别为rsv-t = 0.1838；rsi-t = 0.1133）。本研究表明电压幅度与阻抗值之间存在相关性，因此阻抗可用于致心律失常基质的表征。
