Wu Hanbai, Zhou Xiong, Zhi Chuanwei, Wang Cong, Chen Yuhan, Si Yifan, Yang Jieqiong, Zhang Qi, Lam Raymond H W, Qin Tingwu, Fu Guibing, Xiong Zhu, Hu Jinlian
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China.
City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, China.
Adv Healthc Mater. 2025 Mar;14(7):e2404266. doi: 10.1002/adhm.202404266. Epub 2025 Jan 10.
Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing.
烧伤护理和治疗与其他类型的伤口明显不同，因为它们更容易感染，并且在烧伤后难以维持液体平衡。此外，有限的自我愈合能力加剧了疤痕形成的可能性，使恢复过程更加复杂。为了解决这些问题，设计了一种不对称伤口敷料，其包括载有槲皮素的聚（3-羟基丁酸酯-co-4-羟基丁酸酯）（P34HB@Qu）亲水层和载有氧化锌纳米颗粒的热处理聚偏二氟乙烯（HPVDF@ZnO）疏水层。这种敷料在烧伤治疗的早期阶段提供抗菌性能和渗出液管理，防止感染并维持伤口部位的水分平衡。随着愈合的进展，HPVDF@ZnO的电活性特性和来自P34HB@Qu的槲皮素协同调节细胞迁移和分化，加速伤口愈合并促进无疤痕再生。此外，伤口敷料有助于皮肤附属器的再生。本研究强调了多功能伤口敷料用于烧伤伤口从损伤到无疤痕愈合的时空管理的全周期策略。
