Valenti Vitor Engracia, Chagas André Dos Santos, Chedraui Peter, de Souza Ingrid Soares, Porto Andrey Alves, Sorpreso Isabel Cristina Esposito, Soares Júnior Jose Maria, Zangirolami-Raimundo Juliana, Garner David M, Raimundo Rodrigo Daminello
Autonomic Nervous System Center, Sao Paulo State University, UNESP, Marília, SP, Brazil.
Escuela de Postgrado en Salud, Universidad Espíritu Santo, Samborondón, Ecuador.
Gynecol Endocrinol. 2025 Dec;41(1):2450338. doi: 10.1080/09513590.2025.2450338. Epub 2025 Jan 11.
There is no strong evidence demonstrating whether or not aerobic exercise in conjunction with resistance exercise improves metabolic diabetes markers in postmenopausal women.
To evaluate the effect of aerobic exercise and resistance training on metabolic markers in postmenopausal women with type 2 diabetes mellitus (T2DM) by means of a systematic review and meta-analysis.
The searches were completed using EMBASE, MEDLINE/PubMed, Scopus and Web of Science databases. This study included non-blinded, single or double-blinded randomized control trials and postmenopausal women diagnosed with T2DM. The imposed intervention was aerobic exercise plus any training protocol to strengthen muscle groups for resistance intervention. The outcomes of interest were the blood glucose levels, insulin secretion, homeostasis model assessment-insulin resistance index (HOMA-IR) and glycated hemoglobin (HbA1c). Risk of Bias tools and GRADE were obligatory.
Three studies were included (83 participants). Exercise intervention ranged between two to four days per week. Compared to the control group, in the group submitted to aerobic exercise + resistance training, no significant change was noted for HbA1c (subtotal = mean difference - 0.35 [95% CI: -0.85, 0.15], = .17, and heterogeneity = 0%) (GRADE: very low), nevertheless, HOMA-IR index was significantly improved (subtotal = mean difference -0.52 [95% CI: -0.99, -0.05], = .03, and heterogeneity = 0%) (GRADE: very low).
Despite the very low certainty found in the quality of evidences, our analysis showed that aerobic exercise along with strength exercise seems to improve some metabolic diabetes markers in postmenopausal women with T2DM. There is a need for further studies to support our preliminary findings.
尚无有力证据表明有氧运动联合抗阻运动能否改善绝经后女性的代谢性糖尿病指标。
通过系统评价和荟萃分析，评估有氧运动和抗阻训练对绝经后2型糖尿病（T2DM）女性代谢指标的影响。
使用EMBASE、MEDLINE/PubMed、Scopus和Web of Science数据库完成检索。本研究纳入非盲法、单盲或双盲随机对照试验以及诊断为T2DM的绝经后女性。实施的干预措施为有氧运动加任何用于加强肌肉群的抗阻干预训练方案。感兴趣的结局指标为血糖水平、胰岛素分泌、稳态模型评估胰岛素抵抗指数（HOMA-IR）和糖化血红蛋白（HbA1c）。必须使用偏倚风险工具和GRADE。
纳入三项研究（83名参与者）。运动干预为每周两至四天。与对照组相比，在接受有氧运动+抗阻训练的组中，HbA1c无显著变化（总计=平均差-0.35 [95% CI：-0.85，0.15]，P = 0.17，异质性=0%）（GRADE：极低），然而，HOMA-IR指数显著改善（总计=平均差-0.52 [95% CI：-0.99，-0.05]，P = 0.03，异质性=0%）（GRADE：极低）。
尽管证据质量的确定性极低，但我们的分析表明，有氧运动和力量训练似乎可改善绝经后T2DM女性的一些代谢性糖尿病指标。需要进一步研究来支持我们的初步发现。
