高强度体重训练与联合训练在 2 型糖尿病高危绝经后妇女的肌肉质量、身体表现、炎症标志物和代谢健康方面的变化相当：一项随机对照临床试验。
High-intensity body weight training is comparable to combined training in changes in muscle mass, physical performance, inflammatory markers and metabolic health in postmenopausal women at high risk for type 2 diabetes mellitus: A randomized controlled clinical trial.
机构信息
Exercise Biology Research Group (BioEx), Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
Research Institute of Oncology (IPON) and Gynecology and Obstetrics course, Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
出版信息
Exp Gerontol. 2018 Jul 1;107:108-115. doi: 10.1016/j.exger.2018.02.016. Epub 2018 Feb 19.
OBJECTIVE
This study compared the effects of 12 weeks of high-intensity interval body weight training (HIBWT) with combined training (COMT; aerobic and resistance exercises on body composition, a 6-minute walk test (6MWT; physical performance), insulin resistance (IR) and inflammatory markers in postmenopausal women (PW) at high risk of type 2 diabetes mellitus (TDM2).
METHODS
In this randomized controlled clinical study, 16 PW at high risk of TDM2 were randomly allocated into two groups: HIBWT (n = 8) and COMT (n = 8). The HIBWT group performed a training protocol (length time ~28 min) consisting of ten sets of 60 s of high intensity exercise interspersed by a recovery period of 60 s of low intensity exercise. The COMT group performed a training protocol (length time ~60 min) consisting of a 30 min walk of moderate intensity following by five resistance exercises. All training sessions were performed in the university gym facility three days a week (no consecutive days) for 12 weeks. All outcomes (body composition, muscle function, and IR and inflammatory markers) were assessed at the baseline and at the end of the study.
RESULTS
Both groups increased (P < 0.05) muscle mass index (MMI), 6MWT, and interleukin 1 receptor antagonist and decreased fasting glucose, glycated hemoglobin Insulin, HOMA-IR, and monocyte chemoattractant protein-1 (trend, P = 0.056). HIBWT effects were indistinguishable (P > 0.05) from the effects of COMT. There was a significant (P < 0.05) interaction of time by the group in muscle strength, indicating that only the COMT increased the muscle strength.
CONCLUSIONS
This study suggests that changes in HOMA, IL-1ra, 6MWT, and MMI with HITBW are similar when compared to COMT in PW at high risk of TDM2.
TRIAL REGISTRATION
The patients were part of a 12-week training study (ClinicalTrials.gov Identifier: NCT03200639).
目的
本研究比较了 12 周高强度间歇体重训练（HIBWT）与联合训练（COMT；有氧运动和抗阻运动）对 2 型糖尿病高危绝经后妇女（PW）身体成分、6 分钟步行试验（6MWT；身体表现）、胰岛素抵抗（IR）和炎症标志物的影响。
方法
在这项随机对照临床试验中，16 名 2 型糖尿病高危 PW 被随机分为两组：HIBWT 组（n=8）和 COMT 组（n=8）。HIBWT 组进行了一项训练方案（时长约 28 分钟），包括十组 60 秒高强度运动，穿插 60 秒低强度恢复期。COMT 组进行了一项训练方案（时长约 60 分钟），包括 30 分钟的中等强度步行，随后进行 5 次抗阻运动。所有训练均在大学健身房每周进行 3 天（无连续日），共 12 周。所有结局（身体成分、肌肉功能和 IR 及炎症标志物）均在基线和研究结束时进行评估。
结果
两组均增加了（P<0.05）肌肉质量指数（MMI）、6MWT、白细胞介素 1 受体拮抗剂，降低了空腹血糖、糖化血红蛋白、胰岛素、HOMA-IR 和单核细胞趋化蛋白-1（趋势，P=0.056）。HIBWT 的效果与 COMT 的效果无法区分（P>0.05）。时间与组之间的肌肉力量存在显著交互作用（P<0.05），表明只有 COMT 增加了肌肉力量。
结论
本研究表明，与 COMT 相比，HITBW 引起的 HOMA、IL-1ra、6MWT 和 MMI 的变化在 2 型糖尿病高危 PW 中相似。
试验注册
患者是一项为期 12 周的训练研究的一部分（ClinicalTrials.gov 标识符：NCT03200639）。
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