Xu Jiaqian, Jia Shuangshuang, Xie Ruining, Yan Xin, Chen Lingzhi, Cheng Xiaoyu, Bai Li, Li Yaqing, Wang Yujing, Qiao Yi
School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Department of Public Health, Jining Medical University, Jining, 272000, China.
Eur Geriatr Med. 2025 Feb;16(1):33-44. doi: 10.1007/s41999-024-01147-y. Epub 2025 Jan 11.
Sarcopenia is an age-related disease that is related to nutritional intake and chronic low-grade inflammation. The aim of this study was to investigate the association of dietary intake, inflammatory markers and sarcopenia among the community-dwelling older adults.
A total of 1001 older adults aged 60 and above were recruited. According to the criteria established by the Asian Working Group for Sarcopenia 2019, this paper assessed the presence of sarcopenia and using a Food Frequency Questionnaire to evaluate daily dietary intake. Serum levels of inflammatory markers were measured using the ELISA method.
A total of 1001 participants took part in the study (mean 70.6 years), comprising 396 males and 605 females, the prevalence of sarcopenia was 19.6%. Multivariate analysis revealed that high levels of leucine, methionine, threonine, histidine, aspartic acid, calcium, zinc, and vitamin C were associated with a lower risk of sarcopenia. Higher dietary inflammatory index scores were associated with a higher risk of sarcopenia (OR 1.67, 95% CI 1.12-2.47). Higher tumor necrosis factor-like weak inducer of apoptosis (TWEAK) (OR 1.04, 95% CI 1.02-1.07) was associated with a higher risk of sarcopenia, and a lower skeletal muscle mass, strength, and physical function. Conversely, higher insulin-like growth factor-1 (IGF-1) (OR 0.83, 95% CI 0.74-0.94) and glutathione S-transferase (GST) (OR 0.75, 95% CI 0.61-0.91) were associated with a lower risk of sarcopenia.
This cross-sectional study revealed alterations in amino acid and micronutrient intake among older adults with sarcopenia. The levels of TWEAK were associated with an increased risk of sarcopenia, whereas IGF-1 and GST were associated with a reduced risk of sarcopenia.
肌肉减少症是一种与营养摄入和慢性低度炎症相关的年龄相关性疾病。本研究旨在调查社区居住的老年人的饮食摄入、炎症标志物与肌肉减少症之间的关联。
共招募了1001名60岁及以上的老年人。根据2019年亚洲肌肉减少症工作组制定的标准，本文评估了肌肉减少症的存在情况，并使用食物频率问卷评估每日饮食摄入量。采用酶联免疫吸附测定法测量炎症标志物的血清水平。
共有1001名参与者参加了该研究（平均年龄70.6岁），其中男性396名，女性605名，肌肉减少症的患病率为19.6%。多变量分析显示，高水平的亮氨酸、蛋氨酸、苏氨酸、组氨酸、天冬氨酸、钙、锌和维生素C与较低的肌肉减少症风险相关。较高的饮食炎症指数得分与较高的肌肉减少症风险相关（比值比[OR]为1.67，95%置信区间[CI]为1.12 - 2.47）。较高的肿瘤坏死因子样凋亡弱诱导剂（TWEAK）水平（OR为1.04，95%CI为1.02 - 1.07）与较高的肌肉减少症风险以及较低的骨骼肌质量、力量和身体功能相关。相反，较高的胰岛素样生长因子-1（IGF-1）水平（OR为0.83，95%CI为0.74 - 0.94）和谷胱甘肽S-转移酶（GST）水平（OR为0.75，95%CI为0.61 - 0.91）与较低的肌肉减少症风险相关。
这项横断面研究揭示了患有肌肉减少症的老年人氨基酸和微量营养素摄入的变化。TWEAK水平与肌肉减少症风险增加相关，而IGF-1和GST与肌肉减少症风险降低相关。
