Department of Geriatics, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, People's Republic of China.
Key Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, Hangzhou, 310003, People's Republic of China.
Aging Clin Exp Res. 2022 Oct;34(10):2465-2471. doi: 10.1007/s40520-022-02180-2. Epub 2022 Aug 13.
Sarcopenia is an age-associated decline in muscle mass that negatively affects the metabolic rate, strength, and function of the body and ultimately leads to a decrease in quality of life. Insulin-like growth factor 1 (IGF-1) is a modulator of muscle mass and muscle function. There is evidence that IGF-1 is related to the appendicular skeletal muscle mass index (ASMI) and grip strength. The aim of this study was to explore the relationship between serum IGF-1 levels and sarcopenia in older people.
In this cross-sectional survey of 984 people older than 60 years old, we used the 2019 criteria of the Asian Working Group for Sarcopenia (AWGS) to define sarcopenia. We collected demographic variables, measured ASMI and grip strength, and detected serum IGF-1 data. The levels of serum IGF-1 were separated into quintiles (Q1-Q5).
Adjusted for age, education level, smoking, number of diseases and BMI, the multivariable linear regression analysis revealed that serum IGF-1 levels were related to ASMI in elderly men (coefficient = 0.03, 95% CI = 0.02-0.05, P < 0.001) but were not related to their grip strength. There was no significant relationship between serum IGF-1 levels and ASMI or grip strength in elderly women. The multivariable log-binomial regression analysis showed that higher serum IGF-1 levels were associated with a lower prevalence of sarcopenia in elderly men (prevalence ratio (PR) = 0.99, 95% CI = 0.98-1.00, P < 0.05) but not in elderly women.
Serum IGF-1 levels were highly correlated with sarcopenia in older men. Further studies are needed to further explore the possible reasons for the observed difference between genders. Serum IGF-1 might predict sarcopenia prevalence in elderly men.
肌肉减少症是一种与年龄相关的肌肉质量下降，它会对新陈代谢率、力量和身体功能产生负面影响，最终导致生活质量下降。胰岛素样生长因子 1（IGF-1）是肌肉质量和肌肉功能的调节剂。有证据表明，IGF-1 与四肢骨骼肌质量指数（ASMI）和握力有关。本研究旨在探讨老年人血清 IGF-1 水平与肌肉减少症的关系。
在这项对 984 名 60 岁以上老年人的横断面调查中，我们使用 2019 年亚洲肌肉减少症工作组（AWGS）标准来定义肌肉减少症。我们收集了人口统计学变量，测量了 ASMI 和握力，并检测了血清 IGF-1 数据。血清 IGF-1 水平分为五组（Q1-Q5）。
调整年龄、教育水平、吸烟、疾病数量和 BMI 后，多变量线性回归分析显示，血清 IGF-1 水平与老年男性的 ASMI 相关（系数=0.03，95%CI=0.02-0.05，P<0.001），但与他们的握力无关。在老年女性中，血清 IGF-1 水平与 ASMI 或握力之间没有显著关系。多变量二项逻辑回归分析显示，较高的血清 IGF-1 水平与老年男性肌肉减少症的患病率较低相关（患病率比（PR）=0.99，95%CI=0.98-1.00，P<0.05），但在老年女性中则不然。
血清 IGF-1 水平与老年男性肌肉减少症高度相关。需要进一步的研究来进一步探讨观察到的性别差异的可能原因。血清 IGF-1 可能预测老年男性肌肉减少症的患病率。
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