Vo Han T, Dao Thang V, Do Tinh X, Do Binh N, Nguyen Tan T, Pham Khue M, Vu Vinh H, Pham Linh V, Nguyen Lien T H, Le Lan T H, Nguyen Hoang C, Tran Tuan V, Nguyen Trung H, Nguyen Anh T, Nguyen Hoan V, Nguyen Phuoc B, Pham Thu T M, Dao Tien D, Le Thuy T, Nguyen Thao T P, Tran Cuong Q, Nguyen Kien T, Duong Tuyen V
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110-31, Taiwan; Department of Psychiatry, Hue University of Medicine and Pharmacy, Hue University, Hue 491-20, Viet Nam.
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110-31, Taiwan; Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi 121-08, Viet Nam.
Public Health. 2025 Feb;239:87-93. doi: 10.1016/j.puhe.2024.12.032. Epub 2025 Jan 10.
We investigated the effect modification of health literacy (HL) in ameliorating the negative impact of underlying health conditions (UHC) on long COVID among non-hospitalized and hospitalized survivors.
An online cross-sectional study was conducted in Vietnam from December 2021 to October 2022.
A sample of 4507 participants recruited from 18 hospitals and health centers were those aged 18 or older, had contracted COVID-19 for at least 28 days, and were not in the acute phase of reinfection. Participants reported their long COVID symptoms, UHC, health literacy, socio-demographics, clinical parameters, the COVID-19 impact battery disability scale, and health-related behaviors. The logistic regression models were used to examine the associations and interactions.
Underlying health conditions were associated with a higher likelihood of long COVID in non-hospitalized participants (adjusted odds ratio, aOR = 2.10 [1.61, 2.61]; p < 0.001), and hospitalized ones (aOR = 2.26 [1.87, 2.73]; p < 0.001). In non-hospitalized participants, higher HL scores were significantly linked to a reduced likelihood of experiencing long COVID (aOR = 0.96 [0.95, 0.97]; p < 0.001). Furthermore, HL moderated the adverse effect of underlying health conditions (UHC) on long COVID in this group (aOR = 0.97 [0.94-0.99]; p = 0.042). In hospitalized participants, although higher HL scores were also associated with a lower risk of long COVID (aOR = 0.99 [0.98-0.99]; p = 0.036), HL did not significantly mitigate the negative impact of UHC on long COVID (aOR = 1.01 [0.99-1.03]; p = 0.332).
In non-hospitalized individuals, high health literacy ameliorated the negative impact of UHC on long COVID. Such effects of health literacy were not observed in hospitalized COVID-19 survivors.
我们研究了健康素养（HL）在减轻潜在健康状况（UHC）对非住院和住院康复者长期新冠负面影响方面的效应修正作用。
2021年12月至2022年10月在越南进行了一项在线横断面研究。
从18家医院和健康中心招募了4507名参与者，年龄在18岁及以上，感染新冠病毒至少28天，且不在再次感染的急性期。参与者报告了他们的长期新冠症状、潜在健康状况、健康素养、社会人口统计学、临床参数、新冠病毒影响综合残疾量表以及与健康相关的行为。使用逻辑回归模型来检验关联和相互作用。
潜在健康状况与非住院参与者出现长期新冠的可能性较高相关（调整后的优势比，aOR = 2.10 [1.61, 2.61]；p < 0.001），在住院参与者中也是如此（aOR = 2.26 [1.87, 2.73]；p < 0.001）。在非住院参与者中，较高的健康素养得分与经历长期新冠的可能性降低显著相关（aOR = 0.96 [0.95, 0.97]；p < 0.001）。此外，健康素养缓和了该组中潜在健康状况对长期新冠的不利影响（aOR = 0.97 [0.94 - 0.99]；p = 0.042）。在住院参与者中，虽然较高的健康素养得分也与长期新冠风险较低相关（aOR = 0.99 [0.98 - 0.99]；p = 0.036），但健康素养并未显著减轻潜在健康状况对长期新冠的负面影响（aOR = 1.01 [0.99 - 1.0
