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基于互联网的认知行为疗法对使用药物治疗的成人注意力缺陷多动障碍(ADHD)患者的疗效:一项随机对照试验。

Efficacy of internet-based cognitive behavioral therapy for medicated adults with attention-deficit/hyperactivity disorder (ADHD): A randomized controlled trial.

作者信息

Zhang Shi-Yu, Pan Mei-Rong, Zhang Li-Qian, Li Hai-Mei, Zhao Meng-Jie, Dong Min, Si Fei-Fei, Liu Lu, Wang Yu-Feng, Qian Qiu-Jin

机构信息

Peking University Sixth Hospital/ Institute of Mental Health, Beijing, 100191, PR China; NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, PR China.

Peking University Sixth Hospital/ Institute of Mental Health, Beijing, 100191, PR China; NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, PR China.

出版信息

Psychiatry Res. 2025 Feb;344:116352. doi: 10.1016/j.psychres.2025.116352. Epub 2025 Jan 5.

Abstract

BACKGROUND

Cognitive behavioral therapy (CBT) is an effective treatment for adults with attention-deficit/hyperactivity disorder (ADHD), but its use is limited by poor accessibility and time constraints-barriers that internet-based CBT (iCBT) may help overcome. This trial aimed to explore the short- and long-term efficacy of iCBT in medicated adults with ADHD.

METHODS

Eighty-six adults with ADHD were randomized into two groups: the iCBT combined with medication group (iCBT+M, n = 43) and the medication-only group (n = 43). The iCBT+M group received 12 weeks of iCBT with ongoing medication, while the medication-only group continued with medication alone. The primary outcome was the change in ADHD symptoms. Secondary outcomes included emotional symptoms, executive function, quality of life, and global functioning. Outcomes were assessed at baseline, post-treatment (T1), 6-month (T2), and 12-month follow-up (T3). Mixed linear models were used to assess the differences in outcomes between the two groups at each follow-up point.

RESULTS

Compared to the medication-only group, the iCBT+M group showed greater improvements in ADHD symptoms (d = 0.50 at T1/T2, 0.59 at T3), executive function (d = 0.87 at T1, 0.49 at T2, 0.25 at T3), quality of life (d = -0.74 at T1, -0.59 at T2, -0.28 at T3), global functioning (d = 0.66 at T1, 0.85 at T2, 0.42 at T3), and anxiety (d = 0.43 at T1).

CONCLUSION

iCBT interventions may benefit medicated adults with ADHD by improving core symptoms, executive function, quality of life, and overall functioning, with effects sustained for 12 months.

摘要

背景

认知行为疗法(CBT)是治疗成人注意力缺陷多动障碍(ADHD)的一种有效方法,但其应用受到可及性差和时间限制的制约,而基于互联网的CBT(iCBT)可能有助于克服这些障碍。本试验旨在探讨iCBT对正在服药的ADHD成人的短期和长期疗效。

方法

86名ADHD成人被随机分为两组:iCBT联合药物治疗组(iCBT+M,n = 43)和单纯药物治疗组(n = 43)。iCBT+M组接受为期12周的iCBT并持续用药,而单纯药物治疗组继续仅接受药物治疗。主要结局是ADHD症状的变化。次要结局包括情绪症状、执行功能、生活质量和整体功能。在基线、治疗后(T1)、6个月(T2)和12个月随访(T3)时评估结局。使用混合线性模型评估两组在每个随访点的结局差异。

结果

与单纯药物治疗组相比,iCBT+M组在ADHD症状(T1/T2时d = 0.50,T3时d = 0.59)、执行功能(T1时d = 0.87,T2时d = 0.49,T3时d = 0.25)、生活质量(T1时d = -0.74,T2时d = -0.59,T3时d = -0.28)、整体功能(T1时d = 0.66,T2时d = 0.85,T3时d = 0.42)和焦虑(T1时d = 0.43)方面有更大改善。

结论

iCBT干预可能通过改善核心症状、执行功能、生活质量和整体功能使正在服药的ADHD成人受益,且效果可持续12个月。

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