久坐时间和特定强度身体活动与癌症死亡率的联合关联：一项基于设备的对72458名英国成年人的队列研究。

Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults.

作者信息

Rezende Leandro F M, Ahmadi Matthew, Ferrari Gerson, Del Pozo Cruz Borja, Lee I-Min, Friedenreich Christine M, Stamatakis Emmanuel

机构信息

Department of Preventive Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia, Chile.

出版信息

J Phys Act Health. 2025 Jan 25;22(3):398-402. doi: 10.1123/jpah.2024-0436. Print 2025 Mar 1.

DOI:10.1123/jpah.2024-0436

PMID:39798552

Abstract

BACKGROUND

There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.

METHODS

Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day). Cox regression was performed to estimate hazard ratios (HR) and 95% confidence intervals (CIs) for joint associations of sedentary time and intensity-specific PA (light [LPA], moderate [MPA], and vigorous PA [VPA]) with cancer mortality (reference group: high intensity-specific PA and low sedentary time) adjusted for confounders and mutually adjusted for other PA intensities.

RESULTS

Associations between sedentary time and cancer mortality were stronger among participants with low PA, irrespective of the intensity. Compared with participants with lower sedentary time (<11 h/d) and high MPA (median of 49 min/d), HR were 1.27 (95% CI, 0.90-1.78) for high sedentary time and high MPA, 1.35 (95% CI, 1.03-1.77) for high sedentary time and medium MPA (49 min/d), and 1.49 (95% CI, 1.15-1.92) for high sedentary time and low MPA (13 min/d). HR for high sedentary time and low light PA (61 min/d) and high sedentary time and low vigorous PA (1 min/d) were 1.25 (95% CI, 1.02-1.59) and 1.57 (95% CI, 1.20-2.06), respectively.

CONCLUSIONS

Relatively large amounts of LPA and MPA and small amounts of VPA appeared to attenuate the association between sedentary time and cancer mortality.

摘要

背景

尚无研究探讨基于设备测量的久坐时间与身体活动（PA）对癌症死亡率的前瞻性联合关联。我们在英国生物银行的72458名成年人中，研究了久坐时间和特定强度PA（轻度[LPA]、中度[MPA]和剧烈PA[VPA]）与癌症死亡率的联合关联。

方法

参与者在其优势手腕上佩戴Axivity AX3加速度计至少3天（至少有1个周末日）。采用Cox回归来估计久坐时间和特定强度PA（LPA、MPA和VPA）与癌症死亡率联合关联的风险比（HR）和95%置信区间（CI）（参照组：高强度特定PA和低久坐时间），并对混杂因素进行调整，以及对其他PA强度进行相互调整。

结果

无论强度如何，在PA较低的参与者中，久坐时间与癌症死亡率之间的关联更强。与久坐时间较短（<11小时/天）且MPA较高（中位数为49分钟/天）的参与者相比，久坐时间长且MPA高的HR为1.27（95%CI，0.90-1.78），久坐时间长且MPA中等（49分钟/天）的HR为1.35（95%CI，1.03-1.77），久坐时间长且MPA低（13分钟/天）的HR为1.49（95%CI，1.15-1.92）。久坐时间长且LPA低（61分钟/天）以及久坐时间长且VPA低（1分钟/天）的HR分别为1.25（95%CI，1.02-1.59）和1.57（95%CI，1.20-2.06）。