Frey Connor
Department of Medicine, University of British Columbia, 2194 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
J Affect Disord. 2025 Apr 1;374:72-74. doi: 10.1016/j.jad.2025.01.042. Epub 2025 Jan 9.
Quetiapine, an atypical antipsychotic widely prescribed for conditions including schizophrenia and bipolar disorder has been associated with a potential risk of pancreatitis. This study aimed to quantify the association between quetiapine use and the occurrence of pancreatitis using data from the FDA Adverse Events Reporting System. Disproportionality analyses were conducted to evaluate the frequency of pancreatitis reports linked to quetiapine compared to other drugs in the FAERS database. The study identified a significant association between quetiapine and pancreatitis, with a proportional reporting ratio of 30.708, χ of 81,328.63, relative risk ratio of 27.772, and reporting odds ratio of 32.990, indicating that the risk of pancreatitis is approximately 30 times higher in patients taking quetiapine compared to other medications. These findings suggest that quetiapine poses a considerable risk for the development of pancreatitis, particularly in patients with predisposing factors such as hypertriglyceridemia. This study emphasizes the need for physicians to exercise heightened caution when prescribing quetiapine. While this study provides strong evidence of an association, causality cannot be definitively established, highlighting the necessity for further research to explore the underlying mechanisms and to develop strategies to mitigate this risk.
喹硫平是一种广泛用于治疗包括精神分裂症和双相情感障碍等病症的非典型抗精神病药物，它与胰腺炎的潜在风险有关。本研究旨在利用美国食品药品监督管理局（FDA）不良事件报告系统的数据，量化喹硫平使用与胰腺炎发生之间的关联。进行了不成比例分析，以评估在FAERS数据库中与其他药物相比，与喹硫平相关的胰腺炎报告频率。该研究确定了喹硫平与胰腺炎之间存在显著关联，比例报告比为30.708，χ值为81,328.63，相对风险比为27.772，报告比值比为32.990，这表明服用喹硫平的患者发生胰腺炎的风险比服用其他药物的患者高约30倍。这些发现表明，喹硫平对胰腺炎的发生构成了相当大的风险，特别是在有高甘油三酯血症等易感因素的患者中。本研究强调医生在开具喹硫平处方时需要格外谨慎。虽然这项研究提供了强有力的关联证据，但不能明确确定因果关系，这突出了进一步研究以探索潜在机制并制定降低这种风险策略的必要性。
