非甾体抗炎药与消化性溃疡穿孔
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.
作者信息
Collier D S, Pain J A
出版信息
Gut. 1985 Apr;26(4):359-63. doi: 10.1136/gut.26.4.359.
Abstract
A retrospective study is reported in which the ingestion of non-steroidal anti-inflammatory drugs (NSAID) in 269 patients with perforated peptic ulceration and 269 age/sex matched controls admitted between 1973-1982 was compared. A highly significant statistical difference was found (p less than 0.001) in those aged over 65. There was no statistical difference, however, in those aged under 65. Furthermore we have shown a highly statistically significant correlation (p less than 0.0001) between the annual number of patients aged over 65 with perforated peptic ulcers taking NSAID and the annual number of prescriptions issued for these drugs in the region. No such correlation was found for patients aged under 65 years. We suggest that the elderly especially women are unduly susceptible to NSAID associated peptic ulcer perforation, and discuss factors that may account for this.
摘要
本文报告了一项回顾性研究，比较了1973年至1982年间收治的269例消化性溃疡穿孔患者和269例年龄及性别匹配的对照者使用非甾体抗炎药（NSAID）的情况。在65岁以上人群中发现了高度显著的统计学差异（p<0.001）。然而，65岁以下人群中没有统计学差异。此外，我们还发现，65岁以上服用NSAID的消化性溃疡穿孔患者的年例数与该地区这些药物的年处方数之间存在高度显著的统计学相关性（p<0.0001）。65岁以下患者未发现此类相关性。我们认为老年人尤其是女性对NSAID相关的消化性溃疡穿孔过度敏感，并讨论了可能导致这种情况的因素。
相似文献
1
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.非甾体抗炎药与消化性溃疡穿孔
Gut. 1985 Apr;26(4):359-63. doi: 10.1136/gut.26.4.359.
2
Helicobacter pylori and perforated peptic ulcer prevalence of the infection and role of non-steroidal anti-inflammatory drugs.幽门螺杆菌与消化性溃疡穿孔：感染率及非甾体抗炎药的作用
Dig Liver Dis. 2004 Feb;36(2):116-20. doi: 10.1016/j.dld.2003.10.011.
3
Non-steroidal anti-inflammatory drug ingestion: retrospective study of 272 bleeding or perforated peptic ulcers.非甾体抗炎药摄入：272例出血性或穿孔性消化性溃疡的回顾性研究
Postgrad Med J. 1989 Dec;65(770):892-5. doi: 10.1136/pgmj.65.770.892.
4
Antiinflammatory drugs and emergency surgery for peptic ulcers in the Waikato.怀卡托地区治疗消化性溃疡的抗炎药物与急诊手术
N Z Med J. 1992 Apr 8;105(931):127-9.
5
Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.非甾体抗炎药与消化性溃疡的危及生命并发症
Gut. 1987 May;28(5):527-32. doi: 10.1136/gut.28.5.527.
6
Rising frequency of ulcer perforation in elderly people in the United Kingdom.英国老年人溃疡穿孔发生率上升。
Lancet. 1986 Mar 1;1(8479):489-92. doi: 10.1016/s0140-6736(86)92940-5.
7
Non-steroidal anti-inflammatory drugs and perforated peptic ulcer.非甾体抗炎药与消化性溃疡穿孔
Lancet. 1987 Oct 24;2(8565):968.
8
Fatal peptic ulcer complications and the use of non-steroidal anti-inflammatory drugs, aspirin, and corticosteroids.致命性消化性溃疡并发症以及非甾体抗炎药、阿司匹林和皮质类固醇的使用。
Br Med J (Clin Res Ed). 1987 Nov 14;295(6608):1227-9. doi: 10.1136/bmj.295.6608.1227.
9
Non-steroidal anti-inflammatory drugs and hospital admission for perforated peptic ulcer.
Lancet. 1987 Aug 15;2(8555):380-2. doi: 10.1016/s0140-6736(87)92393-2.
10
Ulcer perforation in the elderly and non-steroidal anti-inflammatory drugs.
Lancet. 1986 Apr 26;1(8487):971-2.
引用本文的文献
1
pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation.pH 响应性 CAP 共聚物（甲基丙烯酸）基水凝胶作为一种有效的控释胃肠道给药平台：制备、表征、体外和体内毒性评价。
Drug Deliv Transl Res. 2019 Apr;9(2):555-577. doi: 10.1007/s13346-018-0486-8.
2
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?非甾体抗炎药引起的溃疡症状真的比普通溃疡的症状更轻微吗？
Gastroenterol Res Pract. 2017;2017:4653250. doi: 10.1155/2017/4653250. Epub 2017 Aug 27.
3
PRESENTATION AND MANAGEMENT OF PERFORATED PEPTIC ULCER DISEASE IN A TERTIARY CENTRE IN SOUTH SOUTH NIGERIA.尼日利亚南部某三级医疗中心的穿孔性消化性溃疡病的诊治情况
J West Afr Coll Surg. 2015 Jul-Sep;5(3):36-48.
4
Clinical profile and outcome of surgical treatment of perforated peptic ulcers in Northwestern Tanzania: A tertiary hospital experience.坦桑尼亚西北部穿孔性消化性溃疡手术治疗的临床特征和结局：一家三级医院的经验。
World J Emerg Surg. 2011 Aug 26;6:31. doi: 10.1186/1749-7922-6-31.
5
Changes in the localization of perforated peptic ulcer and its relation to gender and age of the patients throughout the last 45 years.在过去的 45 年中，穿孔性消化性溃疡定位的变化及其与患者性别和年龄的关系。
World J Surg. 2011 Apr;35(4):811-6. doi: 10.1007/s00268-010-0917-2.
6
Non-steroidal Anti-inflammatory Drugs: Monitoring to help prevent serious adverse effects.非甾体抗炎药：监测以帮助预防严重不良反应。
Can Fam Physician. 1991 Jan;37:171-80.
7
Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002.质子泵抑制剂引入后消化性溃疡并发症发病率的下降，一项对1974年至2002年瑞典人群的研究。
BMC Gastroenterol. 2009 Apr 20;9:25. doi: 10.1186/1471-230X-9-25.
8
Peptic ulcer and non-steroidal anti-inflammatory agents.消化性溃疡与非甾体抗炎药
Gut. 1987 Jan;28(1):111. doi: 10.1136/gut.28.1.111.
9
The histopathology of non-steroidal anti-inflammatory drug induced gastroduodenal damage: correlation with Helicobacter pylori, ulcers, and haemorrhagic events.非甾体抗炎药所致胃十二指肠损伤的组织病理学：与幽门螺杆菌、溃疡及出血事件的相关性
J Clin Pathol. 2001 Jul;54(7):521-5. doi: 10.1136/jcp.54.7.521.
10
Eradication of Helicobacter pylori prevents recurrence of ulcer after simple closure of duodenal ulcer perforation: randomized controlled trial.根除幽门螺杆菌可预防十二指肠溃疡穿孔单纯缝合术后溃疡复发：随机对照试验。
Ann Surg. 2000 Feb;231(2):153-8. doi: 10.1097/00000658-200002000-00001.
本文引用的文献
1
Peptic ulcer in twon and country.城乡的消化性溃疡
Br J Prev Soc Med. 1959 Jul;13(3):131-8. doi: 10.1136/jech.13.3.131.
2
Civilisation and peptic ulcer.文明与消化性溃疡
Lancet. 1962 Jan 20;1(7221):115-9.
3
Stilboestrol, phenobarbitone, and diet in chronic duodenal ulcer. A factorial therapeutic trial.己烯雌酚、苯巴比妥与慢性十二指肠溃疡的饮食。一项析因治疗试验。
Br Med J. 1960 Aug 20;2(5198):559-66. doi: 10.1136/bmj.2.5198.559.
4
Indomethacin and perforated duodenal ulcer.吲哚美辛与十二指肠溃疡穿孔
Br Med J. 1980 Feb 16;280(6212):448. doi: 10.1136/bmj.280.6212.448.
5
Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs.静脉注射吲哚美辛和阿司匹林会降低犬的基础胃黏膜血流量。
Am J Physiol. 1980 Feb;238(2):G131-4. doi: 10.1152/ajpgi.1980.238.2.G131.
6
Inadequacy of the literature on the relationship between drugs, ulcers, and gastrointestinal bleeding.关于药物、溃疡和胃肠道出血之间关系的文献不足。
Gastroenterology. 1982 Feb;82(2):373-6.
7
Perforated peptic ulcer in south-west Scotland 1966-1980.1966 - 1980年苏格兰西南部的穿孔性消化性溃疡
J R Coll Surg Edinb. 1983 Jan;28(1):19-23.
8
What is happening to peptic ulcer?消化性溃疡是怎么回事？
Br Med J (Clin Res Ed). 1982 Apr 10;284(6322):1063-4. doi: 10.1136/bmj.284.6322.1063.
9
Prophylactic effect of dietary fibre in duodenal ulcer disease.
Lancet. 1982 Oct 2;2(8301):736-9. doi: 10.1016/s0140-6736(82)90922-9.
10
20 years of hospital admissions for peptic ulcer in England and Wales.英格兰和威尔士因消化性溃疡住院20年的情况。
Lancet. 1981 Jun 13;1(8233):1302-4. doi: 10.1016/s0140-6736(81)92470-3.
Zotero 插件