Rodrigues Uggioni Maria Laura, Ronsani Leticia, Motta Sophia, Denoni Júnior João Carlos, Marçal Fernanda, Dagostin Ferraz Sarah, Rosa Maria Inês, Colonetti Tamy
Laboratory of Translational Biomedicine, Universidade Do Extremo Sul Catarinense, Criciúma, Brazil.
Medical student, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Nutr Metab Cardiovasc Dis. 2025 Apr;35(4):103827. doi: 10.1016/j.numecd.2024.103827. Epub 2024 Dec 6.
Postmenopausal women experience an increase in cardiovascular, sexual, and emotional changes that can significantly impact their quality of life. Although phytoestrogens offer therapeutic benefits, our understanding of resveratrol's effects remains limited. This study aims to evaluate the effects of using resveratrol on the lipid profile of postmenopausal women.
We conducted a systematic review using search terms like "postmenopausal" and "resveratrol" and their synonyms. Two reviewers handled study selection and data extraction. Randomized clinical trials assessing resveratrol in post-menopausal women were included. The meta-analysis on total cholesterol levels found no significant difference between groups, Standardized Mean Difference (SMD) -0.09 (95 % Confidence Interval (CI) -0.39 to 0.22, p = 0.59; I2 = 0 %, 2 studies, low-quality evidence). No significant differences were found in high-density lipoprotein (HDL) levels, SMD 0.00 (95 % CI -0.31 to 0.31, p = 1; I2 = 0 %, 2 studies, low-quality evidence), Low-Density Lipoprotein (LCD) levels, SMD -0.10 (95 % CI -0.40 to 0.21, p = 0.54; I2 = 0 %, 2 studies, low-quality evidence), and triglyceride levels, SMD -0.12 (95 % CI -0.18 to 0.43, p = 0.43; I2 = 0 %, 2 studies, low-quality evidence).
This review concludes there's limited evidence for recommendations; further studies with higher doses, longer supplementation durations, and exploration of outcomes are needed to clarify therapeutic potential.
绝经后女性会经历心血管、性和情绪方面的变化，这些变化会显著影响她们的生活质量。尽管植物雌激素具有治疗益处，但我们对白藜芦醇作用的了解仍然有限。本研究旨在评估使用白藜芦醇对绝经后女性血脂谱的影响。
我们使用“绝经后”和“白藜芦醇”及其同义词等检索词进行了系统评价。两名评审员负责研究选择和数据提取。纳入了评估白藜芦醇对绝经后女性影响的随机临床试验。对总胆固醇水平的荟萃分析发现，各组之间无显著差异，标准化均数差（SMD）为-0.09（95%置信区间（CI）为-0.39至0.22，p = 0.59；I² = 0%，2项研究，低质量证据）。高密度脂蛋白（HDL）水平、SMD为0.00（95%CI为-0.31至0.31，p = 1；I² = 0%，2项研究，低质量证据）、低密度脂蛋白（LCD）水平、SMD为-0.10（95%CI为-0.40至0.21，p = 0.54；I² = 0%，2项研究，低质量证据）和甘油三酯水平、SMD为-0.12（95%CI为-0.18至0.43，p = 0.43；I² = 0%，2项研究，低质量证据）均无显著差异。
本综述得出结论，支持推荐的证据有限；需要进行更高剂量、更长补充时间和探索更多结果的进一步研究，以阐明其治疗潜力。
