Gerash University of Medical Sciences, Gerash, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1260-1271. doi: 10.1016/j.numecd.2020.03.021. Epub 2020 Mar 28.
Findings on the effects of zinc supplementation on the lipid profile in patients with type 2 diabetes mellitus (T2DM) are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard.
After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of zinc supplementation on lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] in patients with T2DM. Altogether, 9 studies with a total sample size of 424 patients with T2DM were included in the analysis. Combining 9 effect sizes from 9 RCTs, we found a significant lowering effect of zinc supplementation on serum levels of TG (weighted mean difference (WMD): -17.08, 95% CI: -30.59, -3.58 mg/dL, P = 0.01) and TC (WMD: -26.16, 95% CI: -49.69, -2.62 mg/dL, P = 0.02). Although the overall effect of zinc supplementation on LDL-C levels was not significant, a beneficial effect was seen in studies that administered <100 mg/d zinc. Based on the non-linear dose-response analysis, a greater reduction in serum levels of TC and LDL-C following zinc supplementation was seen at <12 weeks' duration of intervention. Unlike the overall effect size, we found a significant increasing effect of zinc supplementation on serum HDL-C concentrations in most subgroups of RCTs according to the subgroup analyses.
We found that zinc supplementation may beneficially influence lipid profile in patients with T2DM.
关于锌补充剂对 2 型糖尿病（T2DM）患者血脂谱影响的研究结果存在争议。本系统综述和荟萃分析旨在总结这方面的现有证据。
在在线数据库中进行系统检索后，我们纳入了研究锌补充剂对 T2DM 患者血脂谱（总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG））影响的随机对照试验（RCT）。共有 9 项研究，共纳入 424 例 T2DM 患者，纳入分析。综合 9 项 RCT 的 9 个效应量，我们发现锌补充剂对血清 TG 水平具有显著降低作用（加权均数差（WMD）：-17.08，95%置信区间（CI）：-30.59，-3.58 mg/dL，P=0.01）和 TC（WMD：-26.16，95%CI：-49.69，-2.62 mg/dL，P=0.02）。虽然锌补充剂对 LDL-C 水平的总体影响不显著，但在给予 <100mg/d 锌的研究中观察到有益效果。基于非线性剂量-反应分析，锌补充干预持续 <12 周时，血清 TC 和 LDL-C 水平的降低更为明显。与总体效应大小不同，我们发现根据亚组分析，在大多数 RCT 亚组中，锌补充剂对血清 HDL-C 浓度具有显著的升高作用。
我们发现锌补充剂可能对 T2DM 患者的血脂谱产生有益影响。
